NMDA and AMPA receptors: old channels, new tricks - PubMed (original) (raw)
Review
NMDA and AMPA receptors: old channels, new tricks
Vikram R Rao et al. Trends Neurosci. 2007 Jun.
Abstract
Learning and memory depend on persistent changes in synaptic strength that require neuronal gene expression. An unresolved question concerns the mechanisms by which activity at synapses is transduced into a nuclear transcriptional response. In the prevailing view, N-methyl-D-aspartate (NMDA)- and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors have distinct roles in controlling synaptic strength: AMPA receptors effect short-term changes in synaptic strength, whereas NMDA receptors regulate genes that are required for the long-term maintenance of these changes. Here, we review recent data on the roles of these two types of receptor in activity-dependent gene expression. We discuss evidence that signals from NMDA receptors and AMPA receptors are integrated to specify transcriptional responses for particular plasticity related genes.
Similar articles
- Kainate receptors are involved in synaptic plasticity.
Bortolotto ZA, Clarke VR, Delany CM, Parry MC, Smolders I, Vignes M, Ho KH, Miu P, Brinton BT, Fantaske R, Ogden A, Gates M, Ornstein PL, Lodge D, Bleakman D, Collingridge GL. Bortolotto ZA, et al. Nature. 1999 Nov 18;402(6759):297-301. doi: 10.1038/46290. Nature. 1999. PMID: 10580501 - Creation of AMPA-silent synapses in the neonatal hippocampus.
Xiao MY, Wasling P, Hanse E, Gustafsson B. Xiao MY, et al. Nat Neurosci. 2004 Mar;7(3):236-43. doi: 10.1038/nn1196. Epub 2004 Feb 15. Nat Neurosci. 2004. PMID: 14966524 - GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
Ferreira JS, Schmidt J, Rio P, Águas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL. Ferreira JS, et al. J Neurosci. 2015 Jun 3;35(22):8462-79. doi: 10.1523/JNEUROSCI.3567-14.2015. J Neurosci. 2015. PMID: 26041915 Free PMC article. - Functions of kinesin superfamily proteins in neuroreceptor trafficking.
Wang N, Xu J. Wang N, et al. Biomed Res Int. 2015;2015:639301. doi: 10.1155/2015/639301. Epub 2015 May 17. Biomed Res Int. 2015. PMID: 26075252 Free PMC article. Review. - Cadherins and synaptic plasticity.
Tai CY, Kim SA, Schuman EM. Tai CY, et al. Curr Opin Cell Biol. 2008 Oct;20(5):567-75. doi: 10.1016/j.ceb.2008.06.003. Epub 2008 Jul 19. Curr Opin Cell Biol. 2008. PMID: 18602471 Review.
Cited by
- Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma.
Georgiou AL, Guo L, Cordeiro MF, Salt TE. Georgiou AL, et al. Neurobiol Dis. 2010 Sep;39(3):344-51. doi: 10.1016/j.nbd.2010.04.019. Epub 2010 May 6. Neurobiol Dis. 2010. PMID: 20451613 Free PMC article. - Pyruvate carboxylation in different model systems studied by (13)C MRS.
Sonnewald U, Rae C. Sonnewald U, et al. Neurochem Res. 2010 Dec;35(12):1916-21. doi: 10.1007/s11064-010-0257-5. Epub 2010 Sep 15. Neurochem Res. 2010. PMID: 20842423 Free PMC article. - Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium.
Enders M, Heider T, Ludwig A, Kuerten S. Enders M, et al. Int J Mol Sci. 2020 Feb 28;21(5):1663. doi: 10.3390/ijms21051663. Int J Mol Sci. 2020. PMID: 32121306 Free PMC article. Review. - The potential role of exercise in chronic stress-related changes in AMPA receptor phenotype underlying synaptic plasticity.
Leem YH. Leem YH. J Exerc Nutrition Biochem. 2017 Dec 31;21(4):11-15. doi: 10.20463/jenb.2017.0037. J Exerc Nutrition Biochem. 2017. PMID: 29370668 Free PMC article. - AMPA receptors control fear extinction through an Arc-dependent mechanism.
Trent S, Barnes P, Hall J, Thomas KL. Trent S, et al. Learn Mem. 2017 Jul 17;24(8):375-380. doi: 10.1101/lm.045013.117. Print 2017 Aug. Learn Mem. 2017. PMID: 28716957 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical