Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease - PubMed (original) (raw)
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Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease
Akhil Wadhera et al. J Am Acad Dermatol. 2007 Oct.
Abstract
Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.
Comment in
- Neoplasia-induced autoimmunity encompasses a spectrum of changes.
Helm TN, Grover R, Beutner E. Helm TN, et al. J Am Acad Dermatol. 2008 Apr;58(4):713. doi: 10.1016/j.jaad.2007.12.022. J Am Acad Dermatol. 2008. PMID: 18342723 No abstract available.
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