Epigenetic decisions in mammalian germ cells - PubMed (original) (raw)
Review
. 2007 Apr 20;316(5823):398-9.
doi: 10.1126/science.1137544.
Affiliations
- PMID: 17446388
- DOI: 10.1126/science.1137544
Review
Epigenetic decisions in mammalian germ cells
Christopher B Schaefer et al. Science. 2007.
Abstract
Specific sequences are designated for de novo DNA methylation at CpG dinucleotides in mammalian germ cells. The result is the long-term transcriptional silencing of the methylated sequences, most of which are retrotransposons and CpG-rich sequences associated with imprinted genes. There is profound sexual dimorphism in both the nature of the sequences that undergo de novo methylation in germ cells and in the mechanism by which de novo methylation is regulated. The restriction of future gene expression by the imposition of heritable methylation patterns in germ cell genomes is characteristic of mammals but is rare in other taxa.
Similar articles
- Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.
Bourc'his D, Bestor TH. Bourc'his D, et al. Nature. 2004 Sep 2;431(7004):96-9. doi: 10.1038/nature02886. Epub 2004 Aug 18. Nature. 2004. PMID: 15318244 - Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse.
Kato Y, Kaneda M, Hata K, Kumaki K, Hisano M, Kohara Y, Okano M, Li E, Nozaki M, Sasaki H. Kato Y, et al. Hum Mol Genet. 2007 Oct 1;16(19):2272-80. doi: 10.1093/hmg/ddm179. Epub 2007 Jul 6. Hum Mol Genet. 2007. PMID: 17616512 - DNA methylation and mammalian epigenetics.
Reik W, Dean W. Reik W, et al. Electrophoresis. 2001 Aug;22(14):2838-43. doi: 10.1002/1522-2683(200108)22:14<2838::AID-ELPS2838>3.0.CO;2-M. Electrophoresis. 2001. PMID: 11565778 Review. - DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
Maatouk DM, Kellam LD, Mann MR, Lei H, Li E, Bartolomei MS, Resnick JL. Maatouk DM, et al. Development. 2006 Sep;133(17):3411-8. doi: 10.1242/dev.02500. Epub 2006 Aug 3. Development. 2006. PMID: 16887828 - Transposon silencing and imprint establishment in mammalian germ cells.
Bestor TH, Bourc'his D. Bestor TH, et al. Cold Spring Harb Symp Quant Biol. 2004;69:381-7. doi: 10.1101/sqb.2004.69.381. Cold Spring Harb Symp Quant Biol. 2004. PMID: 16117671 Review. No abstract available.
Cited by
- Environmental and epigenetic effects upon preimplantation embryo metabolism and development.
Chason RJ, Csokmay J, Segars JH, DeCherney AH, Armant DR. Chason RJ, et al. Trends Endocrinol Metab. 2011 Oct;22(10):412-20. doi: 10.1016/j.tem.2011.05.005. Epub 2011 Jul 7. Trends Endocrinol Metab. 2011. PMID: 21741268 Free PMC article. Review. - Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis.
Nicholas CR, Chavez SL, Baker VL, Reijo Pera RA. Nicholas CR, et al. Endocr Rev. 2009 May;30(3):264-83. doi: 10.1210/er.2008-0034. Epub 2009 Apr 14. Endocr Rev. 2009. PMID: 19366753 Free PMC article. Review. - Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences.
Arpanahi A, Brinkworth M, Iles D, Krawetz SA, Paradowska A, Platts AE, Saida M, Steger K, Tedder P, Miller D. Arpanahi A, et al. Genome Res. 2009 Aug;19(8):1338-49. doi: 10.1101/gr.094953.109. Epub 2009 Jul 7. Genome Res. 2009. PMID: 19584098 Free PMC article. - QDMR: a quantitative method for identification of differentially methylated regions by entropy.
Zhang Y, Liu H, Lv J, Xiao X, Zhu J, Liu X, Su J, Li X, Wu Q, Wang F, Cui Y. Zhang Y, et al. Nucleic Acids Res. 2011 May;39(9):e58. doi: 10.1093/nar/gkr053. Epub 2011 Feb 8. Nucleic Acids Res. 2011. PMID: 21306990 Free PMC article. - Prostate cancer epigenome.
Chinaranagari S, Sharma P, Bowen NJ, Chaudhary J. Chinaranagari S, et al. Methods Mol Biol. 2015;1238:125-40. doi: 10.1007/978-1-4939-1804-1_7. Methods Mol Biol. 2015. PMID: 25421658 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources