The hormonal control of food intake - PubMed (original) (raw)

Review

The hormonal control of food intake

Anthony P Coll et al. Cell. 2007.

Abstract

Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

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Figures

Figure 1

Figure 1

Control of Food Intake by the Hypothalamic Leptin-Melanocortin Pathway The hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake. AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.

Figure 2

Figure 2

Hormones from the Gut and Endocrine Organs Affect Food Intake Hormonal signals derived from the gut and classical endocrine organs, such as the pancreas, thyroid, and adrenal glands act in synergy to effect changes in feeding behavior. CCK, cholecystokinin; OXM, oxyntomodulin; GLP-1, glucagon-like peptide 1; PYY3–36, peptide YY3–36.

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References

    1. Alharbi K.K., Spanakis E., Tan K., Smith M.J., Aldahmesh M.A., O'Dell S.D., Sayer A.A., Lawlor D.A., Ebrahim S., Smith G.D. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum. Mutat. 2007;28:294–302. - PubMed
    1. Alon T., Friedman J.M. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J. Neurosci. 2006;26:389–397. - PMC - PubMed
    1. Balthasar N., Dalgaard L.T., Lee C.E., Yu J., Funahashi H., Williams T., Ferreira M., Tang V., McGovern R.A., Kenny C.D. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005;123:493–505. - PubMed
    1. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., Kenny C.D., McGovern R.A., Chua S.C., Elmquist J.K., Lowell B.B. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004;42:983–991. - PubMed
    1. Bates S.H., Myers M.G., Jr. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 2003;14:447–452. - PubMed

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