A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis - PubMed (original) (raw)

. 2007 Apr 27;316(5824):570-4.

doi: 10.1126/science.1140621.

Gabor Brasnjo, Mitsuko Hayashi, Markus Wölfel, Chiara Collesi, Silvia Giovedi, Andrea Raimondi, Liang-Wei Gong, Pablo Ariel, Summer Paradise, Eileen O'toole, Richard Flavell, Ottavio Cremona, Gero Miesenböck, Timothy A Ryan, Pietro De Camilli

Affiliations

• PMID: 17463283
• DOI: 10.1126/science.1140621

A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis

Shawn M Ferguson et al. Science. 2007.

Abstract

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

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Comment in

• Neuroscience. How to fill a synapse.
  Robinson PJ. Robinson PJ. Science. 2007 Apr 27;316(5824):551-3. doi: 10.1126/science.1142705. Science. 2007. PMID: 17463275 No abstract available.

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