Regulation of the germinal center response by microRNA-155 - PubMed (original) (raw)
. 2007 Apr 27;316(5824):604-8.
doi: 10.1126/science.1141229.
Dinis Pedro Calado, Stefano Casola, K Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David Valenzuela, Jeffery L Kutok, Marc Schmidt-Supprian, Nikolaus Rajewsky, George Yancopoulos, Anjana Rao, Klaus Rajewsky
Affiliations
- PMID: 17463289
- DOI: 10.1126/science.1141229
Regulation of the germinal center response by microRNA-155
To-Ha Thai et al. Science. 2007.
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
Comment in
- Genetics. Erasing microRNAs reveals their powerful punch.
Couzin J. Couzin J. Science. 2007 Apr 27;316(5824):530. doi: 10.1126/science.316.5824.530. Science. 2007. PMID: 17463259 No abstract available.
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