Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients - PubMed (original) (raw)
Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients
D Li et al. Prostaglandins Leukot Essent Fatty Acids. 2007 May.
Abstract
Studies showed that increased dietary intake of n-3 polyunsaturated fatty acids (PUFA) has a cardiovascular beneficial effect. Increased plasma phospholipid (PL) docosahexaenoic acid (22:6n-3) is associated with decreased plasma homocysteine (Hcy). The aim of this study was to investigate the relationship between platelet PL fatty acid and plasma Hcy in middle-aged and geriatric hyperlipaemia patients (50 males, 31 females) and 65 healthy subjects (43 males, 22 females) in Hangzhou, China. Plasma Hcy demonstrated significant positive correlation with adrenic acid (22:4n-6) (r = 0.188, P = 0.018) and negative correlation with 22:6n-3 (r = -0.277, P = 0.001) and the ratio of n-3/n-6 (r = -0.231, P = 0.003) in sex-, age- and BMI-controlled partial correlation analysis. The present results suggest that increased ratio of n-3/n-6 PUFA in platelet PL is associated with decreased thrombotic risks such as plasma Hcy in middle-aged and geriatric hyperlipaemia patients in Hangzhou.
Similar articles
- [Relations of platelet phospholipid fatty acids to thrombotic risk factors in middle-aged and geriatric patients with hyperlipidemia].
Yu XM, Li D, Xie HB, Zhang YH, Wang Q, Zhou XQ, Yu P, Wang LJ. Yu XM, et al. Zhonghua Yi Xue Za Zhi. 2007 Jan 9;87(2):105-8. Zhonghua Yi Xue Za Zhi. 2007. PMID: 17418017 Chinese. - Plasma phospholipid polyunsaturated fatty acids and homocysteine in Chinese type 2 diabetes patients.
Huang T, Asimi S, Lou D, Li D. Huang T, et al. Asia Pac J Clin Nutr. 2012;21(3):394-9. Asia Pac J Clin Nutr. 2012. PMID: 22705429 - Associations of plasma phospholipid fatty acids with plasma homocysteine in Chinese vegetarians.
Huang T, Yu X, Shou T, Wahlqvist ML, Li D. Huang T, et al. Br J Nutr. 2013 May;109(9):1688-94. doi: 10.1017/S000711451200356X. Epub 2012 Aug 31. Br J Nutr. 2013. PMID: 22935202 - Gender differences in the n-3 fatty acid content of tissues.
Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. Childs CE, et al. Proc Nutr Soc. 2008 Feb;67(1):19-27. doi: 10.1017/S0029665108005983. Proc Nutr Soc. 2008. PMID: 18234128 Review. - The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.
Simopoulos AP. Simopoulos AP. Exp Biol Med (Maywood). 2008 Jun;233(6):674-88. doi: 10.3181/0711-MR-311. Epub 2008 Apr 11. Exp Biol Med (Maywood). 2008. PMID: 18408140 Review.
Cited by
- MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations.
Huang T, Tucker K, Lee Y, Crott J, Parnell L, Shen J, Smith C, Ordovas J, Li D, Lai C. Huang T, et al. Nutr Metab Cardiovasc Dis. 2012 Apr;22(4):362-8. doi: 10.1016/j.numecd.2010.07.015. Epub 2010 Dec 24. Nutr Metab Cardiovasc Dis. 2012. PMID: 21185701 Free PMC article. - Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism.
Huang T, Wahlqvist ML, Li D. Huang T, et al. Nutr J. 2012 Jan 19;11:6. doi: 10.1186/1475-2891-11-6. Nutr J. 2012. PMID: 22260268 Free PMC article. - Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes.
Huffman FG, Vaccaro JA, Exebio JC, Ajabshir S, Zarini GG, Shaban LH. Huffman FG, et al. J Nutr Food Sci. 2013;3(1):180. doi: 10.4172/2155-9600.1000180. Epub 2012 Dec 19. J Nutr Food Sci. 2013. PMID: 31667003 Free PMC article. - The Link between Homocysteine and Omega-3 Polyunsaturated Fatty Acid: Critical Appraisal and Future Directions.
Rizzo G, Laganà AS. Rizzo G, et al. Biomolecules. 2020 Feb 2;10(2):219. doi: 10.3390/biom10020219. Biomolecules. 2020. PMID: 32024302 Free PMC article. Review. - Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults.
Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Huang T, et al. J Nutr. 2011 Apr 1;141(4):654-9. doi: 10.3945/jn.110.134353. Epub 2011 Jan 26. J Nutr. 2011. PMID: 21270364 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources