A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila - PubMed (original) (raw)

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. 2007 Apr 27;26(2):160-2.

doi: 10.1016/j.molcel.2007.04.009.

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• PMID: 17466618
• DOI: 10.1016/j.molcel.2007.04.009

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Review

A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila

Renee Chosed et al. Mol Cell. 2007.

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Abstract

Two recent studies in Molecular Cell (Lan et al., 2007; Rudolph et al., 2007) implicate histone demethylation by LSD1 in the regulation of boundaries between silenced and active chromatin domains in both fission yeast and flies, but by distinct mechanisms.

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• S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription.
  Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. Lan F, et al. Mol Cell. 2007 Apr 13;26(1):89-101. doi: 10.1016/j.molcel.2007.02.023. Mol Cell. 2007. PMID: 17434129
• Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.
  Rudolph T, Yonezawa M, Lein S, Heidrich K, Kubicek S, Schäfer C, Phalke S, Walther M, Schmidt A, Jenuwein T, Reuter G. Rudolph T, et al. Mol Cell. 2007 Apr 13;26(1):103-15. doi: 10.1016/j.molcel.2007.02.025. Mol Cell. 2007. PMID: 17434130

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