Prevalence of the metabolic syndrome in individuals with hyperuricemia - PubMed (original) (raw)
Prevalence of the metabolic syndrome in individuals with hyperuricemia
Hyon K Choi et al. Am J Med. 2007 May.
Abstract
Purpose: The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a nationally representative sample of US adults.
Methods: By using data from 8669 participants aged 20 years and more in The Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of the metabolic syndrome at different serum uric acid levels. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III criteria to define the metabolic syndrome.
Results: The prevalences of the metabolic syndrome according to the revised NCEP/ATP III criteria were 18.9% (95% confidence interval [CI], 16.8-21.0) for uric acid levels less than 6 mg/dL, 36.0% (95% CI, 32.5-39.6) for uric acid levels from 6 to 6.9 mg/dL, 40.8% (95% CI, 35.3-46.4) for uric acid levels from 7 to 7.9 mg/dL, 59.7% (95% CI, 53.0-66.4) for uric acid levels from 8 to 8.9 mg/dL, 62.0% (95% CI, 53.0-66.4) for uric acid levels from 9 to 9.9 mg/dL, and 70.7% for uric acid levels of 10 mg/dL or greater. The increasing trends persisted in subgroups stratified by sex, age group, alcohol intake, body mass index, hypertension, and diabetes. For example, among individuals with normal body mass index (<25 kg/m2), the prevalence increased from 5.9% (95% CI, 4.8-7.0), for a uric acid level of less than 6 mg/dL, to 59.0%, (95% CI, 20.1-97.9) for a uric acid level of 10 mg/dL or greater. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower.
Conclusions: These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing levels of serum uric acid. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications.
Similar articles
- Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey.
Choi HK, Ford ES, Li C, Curhan G. Choi HK, et al. Arthritis Rheum. 2007 Feb 15;57(1):109-15. doi: 10.1002/art.22466. Arthritis Rheum. 2007. PMID: 17266099 - Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey.
Choi HK, Curhan G. Choi HK, et al. Arthritis Rheum. 2007 Jun 15;57(5):816-21. doi: 10.1002/art.22762. Arthritis Rheum. 2007. PMID: 17530681 - Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome.
Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Nakagawa T, et al. Nat Clin Pract Nephrol. 2005 Dec;1(2):80-6. doi: 10.1038/ncpneph0019. Nat Clin Pract Nephrol. 2005. PMID: 16932373 Review. - [Is hyperuricemia a cardiovascular risk factor?].
Chizyński K, Rózycka M. Chizyński K, et al. Wiad Lek. 2006;59(5-6):364-7. Wiad Lek. 2006. PMID: 17017483 Review. Polish.
Cited by
- Association between serum level of uric acid in Japanese young patients with coronary spastic angina receiving coronary angiography.
Tanazawa K, Akioka H, Yufu K, Makita T, Sato H, Iwabuchi Y, Ono Y, Yamasaki H, Takahashi M, Ogawa N, Harada T, Mitarai K, Kodama N, Yamauchi S, Takano M, Hirota K, Miyoshi M, Yonezu K, Tawara K, Abe I, Kondo H, Saito S, Fukui A, Fukuda T, Shinohara T, Akiyoshi K, Teshima Y, Takahashi N. Tanazawa K, et al. Heart Vessels. 2024 Oct 5. doi: 10.1007/s00380-024-02469-4. Online ahead of print. Heart Vessels. 2024. PMID: 39368018 - Association Between Serum Uric Acid Levels and Metabolic-Associated Fatty Liver Disease in Southeast China: A Cross-Sectional Study.
Ren S, Chen S, Huang J, Yu R, Wu Y, Peng XE. Ren S, et al. Diabetes Metab Syndr Obes. 2024 Sep 7;17:3343-3354. doi: 10.2147/DMSO.S476045. eCollection 2024. Diabetes Metab Syndr Obes. 2024. PMID: 39268333 Free PMC article. - The association between gout and subsequent cardiovascular events: a retrospective cohort study with 132,000 using propensity score matching in primary care outpatients in Germany.
Sedighi J, Luedde M, Gaensbacher-Kunzendorf J, Sossalla S, Kostev K. Sedighi J, et al. Clin Res Cardiol. 2024 Sep 10. doi: 10.1007/s00392-024-02537-9. Online ahead of print. Clin Res Cardiol. 2024. PMID: 39256222 - Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review.
Saccaro LF, Aimo A, Panichella G, Sentissi O. Saccaro LF, et al. Front Psychiatry. 2024 Mar 4;15:1343427. doi: 10.3389/fpsyt.2024.1343427. eCollection 2024. Front Psychiatry. 2024. PMID: 38501085 Free PMC article. Review. - Serum uric acid levels and prognosis of patients with non-alcoholic fatty liver disease.
Yang X, Lin Y, Huang J, Chi Y, Wu Y, Lin S. Yang X, et al. Sci Rep. 2024 Mar 11;14(1):5923. doi: 10.1038/s41598-024-55845-5. Sci Rep. 2024. PMID: 38467667 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical