Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets - PubMed (original) (raw)

Review

. 2007 Jul 31;581(19):3665-74.

doi: 10.1016/j.febslet.2007.04.033. Epub 2007 Apr 24.

Affiliations

• PMID: 17467701
• DOI: 10.1016/j.febslet.2007.04.033

Free article

Review

Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets

André-Patrick Arrigo et al. FEBS Lett. 2007.

Free article

Abstract

Hsp27 and alphaB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions. In addition, these proteins share anti-apoptotic properties and are tumorigenic when expressed in cancer cells. This review summarizes the current knowledge about Hsp27 and alphaB-crystallin and the implications, either positive or deleterious, of these proteins in pathologies such as neurodegenerative diseases, myopathies, asthma, cataracts and cancers. Approaches towards therapeutic strategies aimed at modulating the expression and/or the activities of Hsp27 and alphaB-crystallin are presented.

PubMed Disclaimer

Similar articles

• N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation.
  Selig EE, Zlatic CO, Cox D, Mok YF, Gooley PR, Ecroyd H, Griffin MDW. Selig EE, et al. J Biol Chem. 2020 Jul 17;295(29):9838-9854. doi: 10.1074/jbc.RA120.012748. Epub 2020 May 16. J Biol Chem. 2020. PMID: 32417755 Free PMC article.
• AlphaA-crystallin interacting regions in the small heat shock protein, alphaB-crystallin.
  Sreelakshmi Y, Santhoshkumar P, Bhattacharyya J, Sharma KK. Sreelakshmi Y, et al. Biochemistry. 2004 Dec 21;43(50):15785-95. doi: 10.1021/bi048151s. Biochemistry. 2004. PMID: 15595834
• Endoplasmic reticulum stress induces the phosphorylation of small heat shock protein, Hsp27.
  Ito H, Iwamoto I, Inaguma Y, Takizawa T, Nagata K, Asano T, Kato K. Ito H, et al. J Cell Biochem. 2005 Aug 1;95(5):932-41. doi: 10.1002/jcb.20445. J Cell Biochem. 2005. PMID: 15864808
• Stress proteins in Alzheimer's disease.
  Smith RC, Rosen KM, Pola R, Magrané J. Smith RC, et al. Int J Hyperthermia. 2005 Aug;21(5):421-31. doi: 10.1080/02656730500133165. Int J Hyperthermia. 2005. PMID: 16048839 Review.
• Transcriptional regulation of small HSP-HSF1 and beyond.
  de Thonel A, Le Mouël A, Mezger V. de Thonel A, et al. Int J Biochem Cell Biol. 2012 Oct;44(10):1593-612. doi: 10.1016/j.biocel.2012.06.012. Epub 2012 Jun 29. Int J Biochem Cell Biol. 2012. PMID: 22750029 Review.

Cited by

• Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid.
  Medeiros M, Zheng X, Novak P, Wnek SM, Chyan V, Escudero-Lourdes C, Gandolfi AJ. Medeiros M, et al. Toxicology. 2012 Jan 27;291(1-3):102-12. doi: 10.1016/j.tox.2011.11.002. Epub 2011 Nov 17. Toxicology. 2012. PMID: 22108045 Free PMC article.
• Novel roles for α-crystallins in retinal function and disease.
  Kannan R, Sreekumar PG, Hinton DR. Kannan R, et al. Prog Retin Eye Res. 2012 Nov;31(6):576-604. doi: 10.1016/j.preteyeres.2012.06.001. Epub 2012 Jun 18. Prog Retin Eye Res. 2012. PMID: 22721717 Free PMC article. Review.
• The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis.
  Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI. Cherneva RV, et al. Int J Chron Obstruct Pulmon Dis. 2012;7:633-40. doi: 10.2147/COPD.S34929. Epub 2012 Oct 4. Int J Chron Obstruct Pulmon Dis. 2012. PMID: 23055712 Free PMC article.
• The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration.
  Schwarz L, Vollmer G, Richter-Landsberg C. Schwarz L, et al. Int J Cell Biol. 2010;2010:717520. doi: 10.1155/2010/717520. Epub 2010 Jan 27. Int J Cell Biol. 2010. PMID: 20150973 Free PMC article.
• Detection and architecture of small heat shock protein monomers.
  Poulain P, Gelly JC, Flatters D. Poulain P, et al. PLoS One. 2010 Apr 7;5(4):e9990. doi: 10.1371/journal.pone.0009990. PLoS One. 2010. PMID: 20383329 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal