More than one reason to rethink the use of peptides in vaccine design - PubMed (original) (raw)
Review
doi: 10.1038/nrd2224.
Affiliations
- PMID: 17473845
- DOI: 10.1038/nrd2224
Review
More than one reason to rethink the use of peptides in vaccine design
Anthony W Purcell et al. Nat Rev Drug Discov. 2007 May.
Abstract
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.
Similar articles
- Epitope discovery and their use in peptide based vaccines.
Dudek NL, Perlmutter P, Aguilar MI, Croft NP, Purcell AW. Dudek NL, et al. Curr Pharm Des. 2010;16(28):3149-57. doi: 10.2174/138161210793292447. Curr Pharm Des. 2010. PMID: 20687873 Review. - Antigenic properties of HCMV peptides displayed by filamentous bacteriophages vs. synthetic peptides.
Ulivieri C, Citro A, Ivaldi F, Mascolo D, Ghittoni R, Fanigliulo D, Manca F, Baldari CT, Li Pira G, Del Pozzo G. Ulivieri C, et al. Immunol Lett. 2008 Aug 15;119(1-2):62-70. doi: 10.1016/j.imlet.2008.04.004. Epub 2008 May 19. Immunol Lett. 2008. PMID: 18538862 - Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design.
Purcell AW, Zeng W, Mifsud NA, Ely LK, Macdonald WA, Jackson DC. Purcell AW, et al. J Pept Sci. 2003 May;9(5):255-81. doi: 10.1002/psc.456. J Pept Sci. 2003. PMID: 12803494 Review. - Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.
Walker J, Ghosh S, Pagnon J, Colantoni C, Newbold A, Zeng W, Jackson DC. Walker J, et al. Vaccine. 2007 Oct 10;25(41):7111-9. doi: 10.1016/j.vaccine.2007.07.047. Epub 2007 Aug 20. Vaccine. 2007. PMID: 17825958 - Design and development of synthetic peptide vaccines: past, present and future.
Bijker MS, Melief CJ, Offringa R, van der Burg SH. Bijker MS, et al. Expert Rev Vaccines. 2007 Aug;6(4):591-603. doi: 10.1586/14760584.6.4.591. Expert Rev Vaccines. 2007. PMID: 17669012 Review.
Cited by
- Screening and identification of linear B-cell epitopes on structural proteins of African Swine Fever Virus.
Lu H, Shao J, Liu W, Gao S, Zhou G, Ning X, Huang H, Liu Y, Chang H. Lu H, et al. Virus Res. 2024 Sep 25;350:199465. doi: 10.1016/j.virusres.2024.199465. Online ahead of print. Virus Res. 2024. PMID: 39306245 Free PMC article. - Development of a Ferritin-Based Nanoparticle Vaccine against Classical Swine Fever.
Song Y, Yuan Z, Ji J, Ruan Y, Li X, Wang L, Zeng W, Wu K, Hu W, Yi L, Ding H, Zhao M, Fan S, Li Z, Chen J. Song Y, et al. Vaccines (Basel). 2024 Aug 22;12(8):948. doi: 10.3390/vaccines12080948. Vaccines (Basel). 2024. PMID: 39204071 Free PMC article. - Cracking the Codes behind Cancer Cells' Immune Evasion.
Mundhara N, Sadhukhan P. Mundhara N, et al. Int J Mol Sci. 2024 Aug 15;25(16):8899. doi: 10.3390/ijms25168899. Int J Mol Sci. 2024. PMID: 39201585 Free PMC article. Review. - Insights into structural vaccinology harnessed for universal coronavirus vaccine development.
Lim CP, Leow CH, Lim HT, Kok BH, Chuah C, Oliveira JIN, Jones M, Leow CY. Lim CP, et al. Clin Exp Vaccine Res. 2024 Jul;13(3):202-217. doi: 10.7774/cevr.2024.13.3.202. Epub 2024 Jul 31. Clin Exp Vaccine Res. 2024. PMID: 39144127 Free PMC article. Review. - Immunogenicity of a peptide-based vaccine for measles: a pilot evaluation in a mouse model.
Quach HQ, Ratishvili T, Haralambieva IH, Ovsyannikova IG, Poland GA, Kennedy RB. Quach HQ, et al. Sci Rep. 2024 Aug 13;14(1):18776. doi: 10.1038/s41598-024-69825-2. Sci Rep. 2024. PMID: 39138335 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources