Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI) - PubMed (original) (raw)

Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI)

Susanne G Mueller et al. Alzheimers Dement. 2005 Jul.

Abstract

With the increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over the last years about the pathomechanisms involved in AD allow for the development of specific treatment strategies aimed at slowing down or even preventing neuronal death in AD. However, this requires also that (1) AD can be diagnosed with high accuracy, because non-AD dementias would not benefit from an AD-specific treatment; (2) AD can be diagnosed in very early stages when any intervention would be most effective; and (3) treatment efficacy can be reliably and meaningfully monitored. Although there currently is no ideal biomarker that would fulfill all these requirements, there is increasing evidence that a combination of currently existing neuroimaging and cerebrospinal fluid (CSF) and blood biomarkers can provide important complementary information and thus contribute to a more accurate and earlier diagnosis of AD. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is exploring which combinations of these biomarkers are the most powerful for diagnosis of AD and monitoring of treatment effects.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Katzman R, Fox P. The world-wide impact of dementia. Projections of prevalence and costs. In: Mayeaux R, Christen Y, editors. Epidemiology of Alzheimer’s disease: from gene to prevention. Berlin, Germany: Springer-Verlag; 1999. pp. 1–17.
    1. Dickson D. In: Neurodegeneration: the molecular pathology of dementia and movement disorders. Dickson D, editor. ISN Neuropath: Press; 2003.
    1. Pratico D, Clark CM, Liun F, Rokach J, Lee VY, Trojanowski JQ. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol. 2002;59(6):972–6. - PubMed
    1. DeKosky ST. Pathology and pathways of Alzheimer’s disease with an update on new developments in treatment. J A m Geriatr Soc. 2003;51(5 Suppl Dementia):S314–20. - PubMed
    1. Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci. 2003;4(1):49–60. - PubMed

Grants and funding

LinkOut - more resources