Roles of AKT signal in breast cancer - PubMed (original) (raw)

Review

doi: 10.2741/2367.

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• PMID: 17485354
• DOI: 10.2741/2367

Review

Roles of AKT signal in breast cancer

Wen Liu et al. Front Biosci. 2007.

Abstract

The PI3K/Akt pathway plays a central role in a variety of cellular processes including cell growth, proliferation, motility and survival in both normal and tumor cells. The PI3K/Akt pathway is also instrumental in epithelial mesenchymal transitions and in angiogenesis during tumorigenesis. Many of the transforming events in breast cancer are a result of enhanced signaling of the PI3K/Akt pathway. Akt therefore is considered to be a rational target for cancer therapies and inhibitors of the PI3K/Akt pathway have been identified. In this review, we discuss the recent information about the functional roles of PI3K/Akt pathway in tumorigenesis and progression of breast cancer.

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