Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice - PubMed (original) (raw)
Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
Jennifer Alamed et al. Nat Protoc. 2006.
Abstract
The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.
Similar articles
- Exposing rats to a predator impairs spatial working memory in the radial arm water maze.
Diamond DM, Park CR, Heman KL, Rose GM. Diamond DM, et al. Hippocampus. 1999;9(5):542-52. doi: 10.1002/(SICI)1098-1063(1999)9:5<542::AID-HIPO8>3.0.CO;2-N. Hippocampus. 1999. PMID: 10560925 - Accelerated senescence prone mouse-8 shows early onset of deficits in spatial learning and memory in the radial six-arm water maze.
Chen GH, Wang YJ, Wang XM, Zhou JN. Chen GH, et al. Physiol Behav. 2004 Oct 15;82(5):883-90. doi: 10.1016/j.physbeh.2004.07.008. Physiol Behav. 2004. PMID: 15451654 - Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease.
Edwards SR, Hamlin AS, Marks N, Coulson EJ, Smith MT. Edwards SR, et al. Clin Exp Pharmacol Physiol. 2014 Oct;41(10):798-806. doi: 10.1111/1440-1681.12277. Clin Exp Pharmacol Physiol. 2014. PMID: 25115283 - Which memory task for my mouse? A systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse model.
Stewart S, Cacucci F, Lever C. Stewart S, et al. J Alzheimers Dis. 2011;26(1):105-26. doi: 10.3233/JAD-2011-101827. J Alzheimers Dis. 2011. PMID: 21558645 Review. - REM sleep deprivation induced by the modified multi-platform method has detrimental effects on memory: A systematic review and meta-analysis.
Diao H, Li Y, Sun W, Zhang J, Wang M, Chen Y, Zhou F, Li X. Diao H, et al. Behav Brain Res. 2023 Oct 2;454:114652. doi: 10.1016/j.bbr.2023.114652. Epub 2023 Aug 29. Behav Brain Res. 2023. PMID: 37652237 Review.
Cited by
- Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease.
Webster SJ, Bachstetter AD, Van Eldik LJ. Webster SJ, et al. Alzheimers Res Ther. 2013 May 24;5(3):28. doi: 10.1186/alzrt182. eCollection 2013. Alzheimers Res Ther. 2013. PMID: 23705774 Free PMC article. - Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease.
Velazquez R, Shaw DM, Caccamo A, Oddo S. Velazquez R, et al. Mol Neurodegener. 2016 Jul 13;11(1):52. doi: 10.1186/s13024-016-0118-z. Mol Neurodegener. 2016. PMID: 27412291 Free PMC article. - Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.
Couch BA, Kerrisk ME, Kaufman AC, Nygaard HB, Strittmatter SM, Koleske AJ. Couch BA, et al. J Comp Neurol. 2013 Apr 15;521(6):1395-408. doi: 10.1002/cne.23239. J Comp Neurol. 2013. PMID: 23047754 Free PMC article. - Overexpression of human wtTDP-43 causes impairment in hippocampal plasticity and behavioral deficits in CAMKII-tTa transgenic mouse model.
Quadri Z, Johnson N, Zamudio F, Miller A, Peters M, Smeltzer S, Hunt JB Jr, Housley SB, Brown B, Kraner S, Norris CM, Nash K, Weeber E, Lee DC, Selenica MB. Quadri Z, et al. Mol Cell Neurosci. 2020 Jan;102:103418. doi: 10.1016/j.mcn.2019.103418. Epub 2019 Nov 6. Mol Cell Neurosci. 2020. PMID: 31705957 Free PMC article. - Platelet factors attenuate inflammation and rescue cognition in ageing.
Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA. Schroer AB, et al. Nature. 2023 Aug;620(7976):1071-1079. doi: 10.1038/s41586-023-06436-3. Epub 2023 Aug 16. Nature. 2023. PMID: 37587343 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- NS48335/NS/NINDS NIH HHS/United States
- AG18478/AG/NIA NIH HHS/United States
- AG15490/AG/NIA NIH HHS/United States
- AG25509/AG/NIA NIH HHS/United States
- AG25711/AG/NIA NIH HHS/United States
- R01 AG015490/AG/NIA NIH HHS/United States
- R01 AG015490-09A1/AG/NIA NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical