Cellular spelunking: exploring adipocyte caveolae - PubMed (original) (raw)
Review
. 2007 Oct;48(10):2103-11.
doi: 10.1194/jlr.R700009-JLR200. Epub 2007 May 11.
Affiliations
- PMID: 17496267
- DOI: 10.1194/jlr.R700009-JLR200
Free article
Review
Cellular spelunking: exploring adipocyte caveolae
Paul F Pilch et al. J Lipid Res. 2007 Oct.
Free article
Abstract
It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the topic that describe various, sometimes contradictory, caveolae functions. Here, we review the field from an "adipocentric" point of view and suggest that caveolae may have a function of particular use for the fat cell, namely the modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways, and it will require further experimental scrutiny to resolve controversies surrounding these possible activities.
Similar articles
- Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes.
Pilch PF, Liu L. Pilch PF, et al. Trends Endocrinol Metab. 2011 Aug;22(8):318-24. doi: 10.1016/j.tem.2011.04.001. Epub 2011 May 17. Trends Endocrinol Metab. 2011. PMID: 21592817 Free PMC article. Review. - Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling.
Souto RP, Vallega G, Wharton J, Vinten J, Tranum-Jensen J, Pilch PF. Souto RP, et al. J Biol Chem. 2003 May 16;278(20):18321-9. doi: 10.1074/jbc.M211541200. Epub 2003 Mar 11. J Biol Chem. 2003. PMID: 12637562 - Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes.
Varela-Guruceaga M, Milagro FI, Martínez JA, de Miguel C. Varela-Guruceaga M, et al. Mol Cell Endocrinol. 2018 Sep 15;473:257-267. doi: 10.1016/j.mce.2018.01.026. Epub 2018 Jan 31. Mol Cell Endocrinol. 2018. PMID: 29407195 - Role of caveolin and caveolae in insulin signaling and diabetes.
Cohen AW, Combs TP, Scherer PE, Lisanti MP. Cohen AW, et al. Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1151-60. doi: 10.1152/ajpendo.00324.2003. Am J Physiol Endocrinol Metab. 2003. PMID: 14607781 Review. - Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes.
Thorn H, Stenkula KG, Karlsson M, Ortegren U, Nystrom FH, Gustavsson J, Stralfors P. Thorn H, et al. Mol Biol Cell. 2003 Oct;14(10):3967-76. doi: 10.1091/mbc.e03-01-0050. Epub 2003 Jul 11. Mol Biol Cell. 2003. PMID: 14517311 Free PMC article.
Cited by
- Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane.
Yue L, Mazzone T. Yue L, et al. J Lipid Res. 2011 Mar;52(3):489-98. doi: 10.1194/jlr.M011809. Epub 2010 Dec 16. J Lipid Res. 2011. PMID: 21169230 Free PMC article. - Lipid rafts and caveolae and their role in compartmentation of redox signaling.
Patel HH, Insel PA. Patel HH, et al. Antioxid Redox Signal. 2009 Jun;11(6):1357-72. doi: 10.1089/ars.2008.2365. Antioxid Redox Signal. 2009. PMID: 19061440 Free PMC article. Review. - Reverse engineering gene network identifies new dysferlin-interacting proteins.
Cacciottolo M, Belcastro V, Laval S, Bushby K, di Bernardo D, Nigro V. Cacciottolo M, et al. J Biol Chem. 2011 Feb 18;286(7):5404-13. doi: 10.1074/jbc.M110.173559. Epub 2010 Nov 30. J Biol Chem. 2011. PMID: 21119217 Free PMC article. - A Role of Caveolae in Trabecular Meshwork Mechanosensing and Contractile Tone.
De Ieso ML, Kuhn M, Bernatchez P, Elliott MH, Stamer WD. De Ieso ML, et al. Front Cell Dev Biol. 2022 Mar 17;10:855097. doi: 10.3389/fcell.2022.855097. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35372369 Free PMC article. - Lipid rafts and caveolae in signaling by growth factor receptors.
de Laurentiis A, Donovan L, Arcaro A. de Laurentiis A, et al. Open Biochem J. 2007;1:12-32. doi: 10.2174/1874091X00701010012. Epub 2007 Sep 13. Open Biochem J. 2007. PMID: 18949068 Free PMC article.