The suicide gene therapy challenge: how to improve a successful gene therapy approach - PubMed (original) (raw)

Review

. 2007 Jul;15(7):1248-52.

doi: 10.1038/sj.mt.6300190. Epub 2007 May 8.

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• PMID: 17505474
• DOI: 10.1038/sj.mt.6300190

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Review

The suicide gene therapy challenge: how to improve a successful gene therapy approach

Chiara Bonini et al. Mol Ther. 2007 Jul.

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Abstract

The transfer of a suicide gene into donor lymphocytes to control alloreactivity in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the widest clinical application of T-cell based gene transfer, as shown by more than 100 patients treated worldwide to date, several phase I-II studies completed, and a registrative phase III study, sponsored by a biotech firm, about to begin. In this mini-review, we will summarize the clinical results obtained to date, and attempt to identify the steps envisaged to optimize the suicide gene therapy approach.

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