PCNA, the maestro of the replication fork - PubMed (original) (raw)

Review

. 2007 May 18;129(4):665-79.

doi: 10.1016/j.cell.2007.05.003.

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• PMID: 17512402
• DOI: 10.1016/j.cell.2007.05.003

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Review

PCNA, the maestro of the replication fork

George-Lucian Moldovan et al. Cell. 2007.

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Abstract

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

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