Neuronal subtype specification in the cerebral cortex - PubMed (original) (raw)

Review

doi: 10.1038/nrn2151.

Affiliations

• PMID: 17514196
• DOI: 10.1038/nrn2151

Review

Neuronal subtype specification in the cerebral cortex

Bradley J Molyneaux et al. Nat Rev Neurosci. 2007 Jun.

Abstract

In recent years, tremendous progress has been made in understanding the mechanisms underlying the specification of projection neurons within the mammalian neocortex. New experimental approaches have made it possible to identify progenitors and study the lineage relationships of different neocortical projection neurons. An expanding set of genes with layer and neuronal subtype specificity have been identified within the neocortex, and their function during projection neuron development is starting to be elucidated. Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity.

PubMed Disclaimer

Similar articles

• The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells.
  Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, Temple S. Shen Q, et al. Nat Neurosci. 2006 Jun;9(6):743-51. doi: 10.1038/nn1694. Epub 2006 May 7. Nat Neurosci. 2006. PMID: 16680166
• The origin and specification of cortical interneurons.
  Wonders CP, Anderson SA. Wonders CP, et al. Nat Rev Neurosci. 2006 Sep;7(9):687-96. doi: 10.1038/nrn1954. Epub 2006 Aug 2. Nat Rev Neurosci. 2006. PMID: 16883309 Review.
• Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion.
  Kriegstein A, Noctor S, Martínez-Cerdeño V. Kriegstein A, et al. Nat Rev Neurosci. 2006 Nov;7(11):883-90. doi: 10.1038/nrn2008. Epub 2006 Oct 11. Nat Rev Neurosci. 2006. PMID: 17033683 Review.
• Cell lineage and regional specification in the mammalian neocortex.
  Walsh C. Walsh C. Perspect Dev Neurobiol. 1993;1(2):75-80. Perspect Dev Neurobiol. 1993. PMID: 7916255 Review.
• The determination of projection neuron identity in the developing cerebral cortex.
  Leone DP, Srinivasan K, Chen B, Alcamo E, McConnell SK. Leone DP, et al. Curr Opin Neurobiol. 2008 Feb;18(1):28-35. doi: 10.1016/j.conb.2008.05.006. Epub 2008 May 26. Curr Opin Neurobiol. 2008. PMID: 18508260 Free PMC article. Review.

Cited by

• Transplanted deep-layer cortical neuroblasts integrate into host neural circuits and alleviate motor defects in hypoxic-ischemic encephalopathy injured mice.
  Wu M, Xu Y, Ji X, Zhou Y, Li Y, Feng B, Cheng Q, He H, Peng X, Zhou W, Chen Y, Xiong M. Wu M, et al. Stem Cell Res Ther. 2024 Nov 13;15(1):422. doi: 10.1186/s13287-024-04049-9. Stem Cell Res Ther. 2024. PMID: 39533375 Free PMC article.
• Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.
  Rasool D, Jahani-Asl A. Rasool D, et al. Transl Psychiatry. 2024 Nov 6;14(1):462. doi: 10.1038/s41398-024-03168-4. Transl Psychiatry. 2024. PMID: 39505843 Free PMC article. Review.
• Radial glia progenitor polarity in health and disease.
  Viola V, Chinnappa K, Francis F. Viola V, et al. Front Cell Dev Biol. 2024 Oct 2;12:1478283. doi: 10.3389/fcell.2024.1478283. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39416687 Free PMC article. Review.
• The Hunchback temporal transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.
  Pollington HQ, Doe CQ. Pollington HQ, et al. bioRxiv [Preprint]. 2024 Oct 7:2024.10.07.616945. doi: 10.1101/2024.10.07.616945. bioRxiv. 2024. PMID: 39416181 Free PMC article. Preprint.
• Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome.
  McRae HM, Leong MPY, Bergamasco MI, Garnham AL, Hu Y, Corbett MA, Whitehead L, El-Saafin F, Sheikh BN, Wilcox S, Hannan AJ, Gécz J, Smyth GK, Thomas T, Voss AK. McRae HM, et al. PLoS Genet. 2024 Oct 15;20(10):e1011428. doi: 10.1371/journal.pgen.1011428. eCollection 2024 Oct. PLoS Genet. 2024. PMID: 39405291 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information