Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5 - PubMed (original) (raw)

Review

Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5

Udo S Gaipl et al. Autoimmunity. 2007 Jun.

Free article

Abstract

Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on the surfaces of dying cells define a highly characteristic membrane signature and enable an unequivocal distinction from vital cells. This way, phagocytosis is initiated and signalling events induced which minimize inflammatory reactions. Therefore, the use of proteins interfering with the clearance process may open up new vistas to improve immunization strategies and may help to understand the mechanisms of autoimmune diseases.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources