Site-specific recombination in the immune system - PubMed (original) (raw)
Review
Site-specific recombination in the immune system
M R Lieber. FASEB J. 1991 Nov.
Abstract
Site-specific DNA recombination has been identified in a wide variety of biological systems. In vertebrates, however, the only identified use of this genetic device is in the immune system. Here it plays a critical role in generating a diverse repertoire of surface receptors to intercept invading microbes and parasites. The mechanism and orchestration of this reaction are intriguing and are relevant to a broad array of related biological and biomedical issues.
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