T(H)1 cells control themselves by producing interleukin-10 - PubMed (original) (raw)
Review
doi: 10.1038/nri2097.
Affiliations
- PMID: 17525751
- DOI: 10.1038/nri2097
Review
T(H)1 cells control themselves by producing interleukin-10
Anne O'Garra et al. Nat Rev Immunol. 2007 Jun.
Abstract
Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.
Similar articles
- IL-10 production by CD4+ effector T cells: a mechanism for self-regulation.
Jankovic D, Kugler DG, Sher A. Jankovic D, et al. Mucosal Immunol. 2010 May;3(3):239-46. doi: 10.1038/mi.2010.8. Epub 2010 Mar 3. Mucosal Immunol. 2010. PMID: 20200511 Free PMC article. Review. - Interleukin-10 production by effector T cells: Th1 cells show self control.
Trinchieri G. Trinchieri G. J Exp Med. 2007 Feb 19;204(2):239-43. doi: 10.1084/jem.20070104. Epub 2007 Feb 12. J Exp Med. 2007. PMID: 17296790 Free PMC article. - CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis.
Anderson CF, Oukka M, Kuchroo VJ, Sacks D. Anderson CF, et al. J Exp Med. 2007 Feb 19;204(2):285-97. doi: 10.1084/jem.20061886. Epub 2007 Feb 5. J Exp Med. 2007. PMID: 17283207 Free PMC article. - The role of IL-27 in the development of T-cell responses during parasitic infections.
Hunter CA, Villarino A, Artis D, Scott P. Hunter CA, et al. Immunol Rev. 2004 Dec;202:106-14. doi: 10.1111/j.0105-2896.2004.00213.x. Immunol Rev. 2004. PMID: 15546389 Review.
Cited by
- Cytokines and chemokines skin gene expression in correlation with immune cells in blood and severity in equine insect bite hypersensitivity.
Jebbawi F, Chemnitzer A, Dietrich M, Pantelyushin S, Lam J, Rhiner T, Keller G, Waldern N, Canonica F, Fettelschoss-Gabriel A. Jebbawi F, et al. Front Immunol. 2024 Jul 15;15:1414891. doi: 10.3389/fimmu.2024.1414891. eCollection 2024. Front Immunol. 2024. PMID: 39076967 Free PMC article. - Differentially Expressed Cell Cycle Genes and STAT1/3-Driven Multiple Cancer Entanglement in Psoriasis, Coupled with Other Comorbidities.
Dorai S, Alex Anand D. Dorai S, et al. Cells. 2022 Nov 30;11(23):3867. doi: 10.3390/cells11233867. Cells. 2022. PMID: 36497125 Free PMC article. - The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Perucha E, et al. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9. Nat Commun. 2019. PMID: 30700717 Free PMC article. - The Presence of Leishmania braziliensis DNA in the Nasal Mucosa of Cutaneous Leishmaniasis Patients and the Search for Possible Clinical and Immunological Patterns of Disease Progression: A Cross Sectional Study.
Barroso DH, Nóbrega OT, de Araújo CN, Freire GSM, Martins SS, Rodrigues BC, Gomes CM, Sampaio RNR. Barroso DH, et al. Front Cell Infect Microbiol. 2021 Oct 14;11:744163. doi: 10.3389/fcimb.2021.744163. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34722337 Free PMC article. - Imbalanced effector and regulatory cytokine responses may underlie mycobacterial immune restoration disease.
Lim A, D'Orsogna L, Price P, French MA. Lim A, et al. AIDS Res Ther. 2008 Apr 29;5:9. doi: 10.1186/1742-6405-5-9. AIDS Res Ther. 2008. PMID: 18442415 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources