In vivo acquisition of prophage in Streptococcus pyogenes - PubMed (original) (raw)
. 2007 Jul;15(7):297-300.
doi: 10.1016/j.tim.2007.05.003. Epub 2007 May 31.
Affiliations
- PMID: 17543527
- DOI: 10.1016/j.tim.2007.05.003
In vivo acquisition of prophage in Streptococcus pyogenes
Vincent A Fischetti. Trends Microbiol. 2007 Jul.
Abstract
Genomic analysis of 12 Streptococcus pyogenes genomes representing six different serotypes reveals that they are poly-lysogenized, with as many as seven separate phage genomes (some of which are defective). Sequence alignments of these genomes (excluding incorporated prophage) have revealed that they are approximately 90% conserved, indicating that their diversity and disease capacity might be phage related. However, because S. pyogenes are only found in humans, how are new phages acquired? In vitro and in vivo experiments show that efficient phage transfer from donor to recipient streptococci occurs in the presence of mammalian cells. This suggests that, through evolution, phage have devised a system whereby progeny phage are induced and transferred to host streptococci at a site where host organisms are more prevalent.
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