The effects of prolonged stress and APOE genotype on memory and cortisol in older adults - PubMed (original) (raw)
The effects of prolonged stress and APOE genotype on memory and cortisol in older adults
Guerry M Peavy et al. Biol Psychiatry. 2007.
Abstract
Background: Chronic elevations in cortisol associated with prolonged stress have been associated with memory loss, as has the apolipoprotein E gene (APOE-epsilon4) genotype. Combined effects of stress and APOE status on memory and cortisol in humans have not been studied.
Methods: A semistructured interview with standardized scoring was used to measure stress level and univariate analysis of variance to assess effects of stress and APOE-epsilon4 status on memory and salivary cortisol in 91 nondemented subjects (mean age 78.8 years).
Results: Low-stress subjects performed better than high-stress subjects on delayed recall of stories (p = .04), word lists (p = .02), and visual designs (p = .04). APOE-epsilon4-negative subjects obtained better scores than epsilon4-positive subjects on immediate (p = < .01) and delayed (p < .01) recall of visual designs. Significant stress by APOE-epsilon4 interaction effects on memory (p = .03) and cortisol (p < .01) resulted from consistently worse memory and higher cortisol concentrations in the high stress, epsilon4-positive group.
Conclusions: These findings are consistent with a model in which prolonged exposure of older, nondemented individuals to stress in the presence of an epsilon4 allele leads to memory decline. Further studies will assess whether stress and APOE-epsilon4 interact to increase the risk of developing Alzheimer's disease.
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References
- Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63:168–74. - PubMed
- Swan GE, Reed T, Jack LM, Miller BL, Markee T, Wolf PA, et al. Differential genetic influence for components of memory in aging adult twins. Arch Neurol. 1999;56:1127–32. - PubMed
- Katzman R, Kawas C. The epidemiology of dementia and Alzheimer’s disease. In: Terry RD, Katzman Robert, Bick Katherine L, editors. Alzheimer’s disease. Raven Press; New York: 1994. pp. 105–122.
- Lindauer R, Olff M, van Meijel E, Carlier I, Gersons B. Cortisol, learning, memory, and attention, in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder. Biol Psychiatry. 2006;59:171–177. - PubMed
- Lupien SJ, de Leon M, de Santi S, Convit A, Tarshish C, Nair NP, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci. 1998;1:69–73. - PubMed
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