Tumor-associated macrophages press the angiogenic switch in breast cancer - PubMed (original) (raw)

Tumor-associated macrophages press the angiogenic switch in breast cancer

Elaine Y Lin et al. Cancer Res. 2007.

Abstract

The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

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