Broad spectrum identification of SUMO substrates in melanoma cells - PubMed (original) (raw)

. 2007 Jun;7(13):2216-21.

doi: 10.1002/pmic.200600971.

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Broad spectrum identification of SUMO substrates in melanoma cells

Anand K Ganesan et al. Proteomics. 2007 Jun.

Abstract

Like phosphorylation, protein sumoylation likely represents a dynamic PTM to alter protein function in support of cell regulatory systems. The broad-spectrum impact of transient or chronic engagement of signal transduction cascades on protein sumoylation has not been explored. Here, we find that epidermal growth factor (EGF) stimulation evokes a rapid alteration in small ubiquitin modifier (SUMO) target selection, while oncogene expression alters steady-state SUMO-protein profiles. A proteomic SUMO target analysis in melanoma cells identified proteins involved in cellular signaling, growth control, and neural differentiation.

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