Copper-catalyzed asymmetric reduction of 3,3-diarylacrylonitriles - PubMed (original) (raw)
. 2007 Jul 5;9(14):2749-51.
doi: 10.1021/ol0712071. Epub 2007 Jun 8.
Affiliations
- PMID: 17555326
- DOI: 10.1021/ol0712071
Copper-catalyzed asymmetric reduction of 3,3-diarylacrylonitriles
Daehyung Lee et al. Org Lett. 2007.
Abstract
CuH-catalyzed enantioselective conjugate reduction of 3,3-diaryl-substituted acrylonitriles is described. A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).
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