Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs - PubMed (original) (raw)
. 2007 Jun;11(6):498-512.
doi: 10.1016/j.ccr.2007.04.011.
Michela Marani, Olivier Pardo, Patricia H Warne, Gavin Kelly, Erik Sahai, Frédéric Elustondo, Jenny Chang, Jillian Temple, Ahmed A Ahmed, James D Brenton, Julian Downward, Barbara Nicke
Affiliations
- PMID: 17560332
- DOI: 10.1016/j.ccr.2007.04.011
Free article
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
Charles Swanton et al. Cancer Cell. 2007 Jun.
Free article
Abstract
Cytotoxic drug resistance is a major cause of cancer treatment failure. We report an RNA interference screen to identify genes influencing sensitivity of different cancer cell types to chemotherapeutic agents. A set of genes whose targeting leads to resistance to paclitaxel is identified, many of which are involved in the spindle assembly checkpoint. Silencing these genes attenuates paclitaxel-induced mitotic arrest and induces polyploidy in the absence of drug. We also identify a ceramide transport protein, COL4A3BP or CERT, whose downregulation sensitizes cancer cells to multiple cytotoxic agents, potentiating endoplasmic reticulum stress. COL4A3BP expression is increased in drug-resistant cell lines and in residual tumor following paclitaxel treatment of ovarian cancer, suggesting that it could be a target for chemotherapy-resistant cancers.
Comment in
- A CERTain role for ceramide in taxane-induced cell death.
Kolesnick R, Altieri D, Fuks Z. Kolesnick R, et al. Cancer Cell. 2007 Jun;11(6):473-5. doi: 10.1016/j.ccr.2007.05.003. Cancer Cell. 2007. PMID: 17560328
Similar articles
- A CERTain role for ceramide in taxane-induced cell death.
Kolesnick R, Altieri D, Fuks Z. Kolesnick R, et al. Cancer Cell. 2007 Jun;11(6):473-5. doi: 10.1016/j.ccr.2007.05.003. Cancer Cell. 2007. PMID: 17560328 - CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.
Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, Speirs V, Hanby AM, Downward J, Tooze SA, Swanton C. Lee AJ, et al. J Pathol. 2012 Feb;226(3):482-94. doi: 10.1002/path.2998. Epub 2011 Oct 19. J Pathol. 2012. PMID: 21953249 - BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance.
Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. Chabalier C, et al. Cell Cycle. 2006 May;5(9):1001-7. doi: 10.4161/cc.5.9.2726. Epub 2006 May 1. Cell Cycle. 2006. PMID: 16639080 - Chromosomal instability, colorectal cancer and taxane resistance.
Swanton C, Tomlinson I, Downward J. Swanton C, et al. Cell Cycle. 2006 Apr;5(8):818-23. doi: 10.4161/cc.5.8.2682. Epub 2006 Apr 17. Cell Cycle. 2006. PMID: 16628000 Review. - Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer.
Coley HM, Hatzimichael E, Blagden S, McNeish I, Thompson A, Crook T, Syed N. Coley HM, et al. Oncotarget. 2012 Jan;3(1):78-83. doi: 10.18632/oncotarget.332. Oncotarget. 2012. PMID: 22289679 Free PMC article. Review.
Cited by
- Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching.
Cabukusta B, Köhlen JA, Richter CP, You C, Holthuis JCM. Cabukusta B, et al. J Biol Chem. 2016 Nov 18;291(47):24735-24746. doi: 10.1074/jbc.M116.749812. Epub 2016 Oct 10. J Biol Chem. 2016. PMID: 27729449 Free PMC article. - A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in a pancreatic cancer cell line.
Mondal P, Alyateem G, Mitchell AV, Gottesman MM. Mondal P, et al. Sci Rep. 2024 Jul 10;14(1):15912. doi: 10.1038/s41598-024-66244-1. Sci Rep. 2024. PMID: 38987356 Free PMC article. - Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
Goldman A, Majumder B, Dhawan A, Ravi S, Goldman D, Kohandel M, Majumder PK, Sengupta S. Goldman A, et al. Nat Commun. 2015 Feb 11;6:6139. doi: 10.1038/ncomms7139. Nat Commun. 2015. PMID: 25669750 Free PMC article. - Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines.
Eschenbrenner J, Winsel S, Hammer S, Sommer A, Mittelstaedt K, Drosch M, Klar U, Sachse C, Hannus M, Seidel M, Weiss B, Merz C, Siemeister G, Hoffmann J. Eschenbrenner J, et al. Front Oncol. 2011 Nov 16;1:44. doi: 10.3389/fonc.2011.00044. eCollection 2011. Front Oncol. 2011. PMID: 22649765 Free PMC article. - Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.
Janssen A, Kops GJ, Medema RH. Janssen A, et al. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19108-13. doi: 10.1073/pnas.0904343106. Epub 2009 Oct 23. Proc Natl Acad Sci U S A. 2009. PMID: 19855003 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources