ENPP1 gene, insulin resistance and related clinical outcomes - PubMed (original) (raw)
Review
ENPP1 gene, insulin resistance and related clinical outcomes
Simonetta Bacci et al. Curr Opin Clin Nutr Metab Care. 2007 Jul.
Abstract
Purpose of review: Insulin resistance plays a significant role in both morbidity and mortality of the general population. Understanding the molecular mechanisms of insulin resistance would help the identification of at-risk individuals in the presymptomatic stage, and the discovery of novel and more effective treatments. The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin receptor signalling and has recently emerged as a key player in the development of insulin resistance. This review will summarize data available on the relationship between ENPP1 and insulin resistance.
Recent findings: Overexpression of ENPP1 in insulin target tissues is an early, intrinsic defect observed in human insulin resistance. A missense ENPP1 single nucleotide polymorphism, K121Q, has been recently described with the Q121 variant being a stronger inhibitor than K121 of insulin receptor function. In addition, the Q121 variant has been repeatedly associated with insulin resistance and related abnormalities including body weight changes, type 2 diabetes and macrovascular complications, thus suggesting a pleiotropic role of the ENPP1 gene on several metabolic abnormalities.
Summary: A deep understanding of ENPP1 mode of action and the mechanisms regulating its expression and function are likely to provide new tools for early identification and treatments of patients at risk for the devastating clinical outcomes related to insulin resistance.
Similar articles
- Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome.
González-Sánchez JL, Zabena C, Martínez-Larrad MT, Martínez-Calatrava MJ, Pérez-Barba M, Serrano-Ríos M. González-Sánchez JL, et al. Clin Endocrinol (Oxf). 2008 May;68(5):724-9. doi: 10.1111/j.1365-2265.2007.03103.x. Epub 2007 Nov 6. Clin Endocrinol (Oxf). 2008. PMID: 17986276 - Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors.
Abate N, Chandalia M, Di Paola R, Foster DW, Grundy SM, Trischitta V. Abate N, et al. Nat Clin Pract Endocrinol Metab. 2006 Dec;2(12):694-701. doi: 10.1038/ncpendmet0367. Nat Clin Pract Endocrinol Metab. 2006. PMID: 17143316 Review. - New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.
Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram JH, Krolewski AS. Bochenski J, et al. Diabetes. 2006 Sep;55(9):2626-30. doi: 10.2337/db06-0191. Diabetes. 2006. PMID: 16936213 - Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease.
Dongiovanni P, Valenti L, Rametta R, Daly AK, Nobili V, Mozzi E, Leathart JB, Pietrobattista A, Burt AD, Maggioni M, Fracanzani AL, Lattuada E, Zappa MA, Roviaro G, Marchesini G, Day CP, Fargion S. Dongiovanni P, et al. Gut. 2010 Feb;59(2):267-73. doi: 10.1136/gut.2009.190801. Gut. 2010. PMID: 20176643
Cited by
- Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus.
Felisbino K, Granzotti JG, Bello-Santos L, Guiloski IC. Felisbino K, et al. Front Physiol. 2021 Jul 21;12:699220. doi: 10.3389/fphys.2021.699220. eCollection 2021. Front Physiol. 2021. PMID: 34366888 Free PMC article. Review. - Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population.
Arikoglu H, Erkoc-Kaya D, Ipekci SH, Gokturk F, Iscioglu F, Korez MK, Baldane S, Gonen MS. Arikoglu H, et al. Mol Biol Rep. 2021 May;48(5):4181-4189. doi: 10.1007/s11033-021-06431-9. Epub 2021 Jun 11. Mol Biol Rep. 2021. PMID: 34117605 - Genetic determinants and early carotid atherosclerosis: is there a role for the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP-1) K121Q polymorphism? Preliminary results in non diabetic individuals.
Coletta P, Barbarossa G, Pergolini D, D'Erasmo L, Renzi A, Mercuri L, Anatra MG, Ciociola E, Verrienti A, Maranghi M. Coletta P, et al. Endocrine. 2012 Dec;42(3):749-51. doi: 10.1007/s12020-012-9771-3. Epub 2012 Aug 17. Endocrine. 2012. PMID: 22899099 No abstract available. - Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.
Prudente S, Morini E, Trischitta V. Prudente S, et al. Nat Rev Endocrinol. 2009 Dec;5(12):682-93. doi: 10.1038/nrendo.2009.215. Nat Rev Endocrinol. 2009. PMID: 19924153 Review. - ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.
Wang H, Gonzalez-Garcia I, Traba J, Jain S, Conteh S, Shin DM, Qi C, Gao Y, Sun J, Kang S, Abbasi S, Naghashfar Z, Yoon J, DuBois W, Kovalchuk AL, Sack MN, Duffy P, Morse HC 3rd. Wang H, et al. Sci Rep. 2017 Dec 19;7(1):17867. doi: 10.1038/s41598-017-18028-z. Sci Rep. 2017. PMID: 29259245 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous