Role of alpha/beta and gamma/delta T cells in renal ischemia-reperfusion injury - PubMed (original) (raw)
. 2007 Sep;293(3):F741-7.
doi: 10.1152/ajprenal.00486.2006. Epub 2007 Jun 13.
Affiliations
- PMID: 17567936
- DOI: 10.1152/ajprenal.00486.2006
Free article
Role of alpha/beta and gamma/delta T cells in renal ischemia-reperfusion injury
Kathrin Hochegger et al. Am J Physiol Renal Physiol. 2007 Sep.
Free article
Abstract
T cells have been implicated in the pathogenesis of renal ischemia-reperfusion injury (IRI). To date existing data about the role of the T cell receptor (Tcr) are contradictory. We hypothesize that the Tcr plays a prominent role in the late phase of renal IRI. Therefore, renal IRI was induced in alpha/beta, gamma/delta T cell-deficient and wild-type mice by clamping renal pedicles for 30 min and reperfusing for 24, 48, 72, and 120 h. Serum creatinine increased equally in all three groups 24 h after ischemia but significantly improved in Tcr-deficient animals compared with wild-type controls after 72 h. A significant reduction in renal tubular injury and infiltration of CD4+ T-cells in both Tcr-deficient mice compared with wild-type controls was detected. Infiltration of alpha/beta T cells into the kidney was reduced in gamma/delta T cell-deficient mice until 72 h after ischemia. In contrast, gamma/delta T cell infiltration was equal in wild-type and alpha/beta T cell-deficient mice, suggesting an interaction between alpha/beta and gamma/delta T cells. Data from gamma/delta T cell-deficient mice were confirmed by in vivo depletion of gamma/delta T cells in C57BL/6 mice. Whereas alpha/beta T cell-deficient mice were still protected after 120 h, gamma/delta T cell-deficient mice showed a "delayed wild-type phenotype" with a dramatic increase in kidney-infiltrating alpha/beta, Tcr-expressing CD4+ T-cells. This report provides further evidence that alpha/beta T cells are major effector cells in renal IRI, whereas gamma/delta T cells play a role as mediator cells in the first 72 h of renal IRI.
Similar articles
- The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury.
Satpute SR, Park JM, Jang HR, Agreda P, Liu M, Gandolfo MT, Racusen L, Rabb H. Satpute SR, et al. J Immunol. 2009 Jul 15;183(2):984-92. doi: 10.4049/jimmunol.0801928. Epub 2009 Jun 26. J Immunol. 2009. PMID: 19561110 - Events that regulate differentiation of alpha beta TCR+ and gamma delta TCR+ T cells from a common precursor.
Kang J, Raulet DH. Kang J, et al. Semin Immunol. 1997 Jun;9(3):171-9. doi: 10.1006/smim.1997.0069. Semin Immunol. 1997. PMID: 9200328 Review. - Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells.
Lefrançois L, Barrett TA, Havran WL, Puddington L. Lefrançois L, et al. Eur J Immunol. 1994 Mar;24(3):635-40. doi: 10.1002/eji.1830240322. Eur J Immunol. 1994. PMID: 7907296 - Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors.
Penninger J, Wallace VA, Kishihara K, Molina T, Krause H, Mak TW. Penninger J, et al. Exp Clin Immunogenet. 1991;8(2):57-74. Exp Clin Immunogenet. 1991. PMID: 1838695 Review.
Cited by
- Lymphocytes and innate immune cells in acute kidney injury and repair.
Lee K, Jang HR, Rabb H. Lee K, et al. Nat Rev Nephrol. 2024 Dec;20(12):789-805. doi: 10.1038/s41581-024-00875-5. Epub 2024 Aug 2. Nat Rev Nephrol. 2024. PMID: 39095505 Review. - A new method for the treatment of myocardial ischemia-reperfusion injury based on γδT cell-mediated immune response.
Luo W, Bian X, Liu X, Zhang W, Xie Q, Feng L. Luo W, et al. Front Cardiovasc Med. 2023 Aug 3;10:1219316. doi: 10.3389/fcvm.2023.1219316. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37600023 Free PMC article. - Inhibition of γδ-TcR or IL17a Reduces T-Cell and Neutrophil Infiltration after Ischemia/Reperfusion Injury in Mouse Liver.
Al Mogrampi S, Boumpoureka C, Afaloniati H, Lagou M, Angelopoulou K, Anestakis D, Tampouratzi ZG, Iliadis S, Antoniadis N, Giakoustidis A, Papalois A, Papadopoulos V, Poutahidis T, Giakoustidis D. Al Mogrampi S, et al. J Clin Med. 2023 Feb 22;12(5):1751. doi: 10.3390/jcm12051751. J Clin Med. 2023. PMID: 36902538 Free PMC article. - Immune Cells Are Differentially Modulated in the Heart and the Kidney during the Development of Cardiorenal Syndrome 3.
Vernier ICS, Neres-Santos RS, Andrade-Oliveira V, Carneiro-Ramos MS. Vernier ICS, et al. Cells. 2023 Feb 13;12(4):605. doi: 10.3390/cells12040605. Cells. 2023. PMID: 36831272 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials