The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity - PubMed (original) (raw)
Review
. 2007 Jun 21;54(6):859-71.
doi: 10.1016/j.neuron.2007.06.001.
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- PMID: 17582328
- DOI: 10.1016/j.neuron.2007.06.001
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Review
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
John T R Isaac et al. Neuron. 2007.
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Abstract
The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a number of forms of long-term synaptic plasticity. Most neuronal AMPARs contain this critical subunit; however, in certain restricted neuronal populations and under certain physiological or pathological conditions, AMPARs that lack this subunit are expressed. There is a current surge of interest in such GluR2-lacking Ca2+-permeable AMPARs in how they affect the regulation of synaptic transmission. Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity.
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