Non-transcriptional control of DNA replication by c-Myc - PubMed (original) (raw)
. 2007 Jul 26;448(7152):445-51.
doi: 10.1038/nature05953. Epub 2007 Jun 27.
Affiliations
- PMID: 17597761
- DOI: 10.1038/nature05953
Non-transcriptional control of DNA replication by c-Myc
David Dominguez-Sola et al. Nature. 2007.
Erratum in
- Author Correction: Non-transcriptional control of DNA replication by c-Myc.
Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Dominguez-Sola D, et al. Nature. 2023 Jul;619(7969):E39. doi: 10.1038/s41586-023-06284-1. Nature. 2023. PMID: 37386298 No abstract available.
Abstract
The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and proliferation and is broadly implicated in tumorigenesis. However, the biological functions required by c-Myc to induce oncogenesis remain elusive. Here we show that c-Myc has a direct role in the control of DNA replication. c-Myc interacts with the pre-replicative complex and localizes to early sites of DNA synthesis. Depletion of c-Myc from mammalian (human and mouse) cells as well as from Xenopus cell-free extracts, which are devoid of RNA transcription, demonstrates a non-transcriptional role for c-Myc in the initiation of DNA replication. Overexpression of c-Myc causes increased replication origin activity with subsequent DNA damage and checkpoint activation. These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions.
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