Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms - PubMed (original) (raw)
Review
Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms
Angela C Rutledge et al. Nutr Rev. 2007 Jun.
Abstract
Emerging evidence suggests that increased dietary consumption of fructose in Western society may be a potentially important factor in the growing rates of obesity and the metabolic syndrome. This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insulin-sensitive tissues. In particular, the roles of cellular signaling molecules including nuclear factor kappa B (NFkB), tumor necrosis factor alpha (TNF-alpha), c-Jun amino terminal kinase 1 (JNK-1), protein tyrosine phosphatase 1B (PTP-1B), phosphatase and tensin homolog deleted on chromosome ten (PTEN), liver X receptor (LXR), farnesoid X receptor (FXR), and sterol regulatory element-binding protein-1c (SREBP-1c) will be addressed. Considering the prevalence and seriousness of the metabolic syndrome, further research on the underlying molecular mechanisms and preventative and curative strategies is warranted.
Similar articles
- How safe is fructose for persons with or without diabetes?
Sánchez-Lozada LG, Le M, Segal M, Johnson RJ. Sánchez-Lozada LG, et al. Am J Clin Nutr. 2008 Nov;88(5):1189-90. doi: 10.3945/ajcn.2008.26812. Am J Clin Nutr. 2008. PMID: 18996851 No abstract available. - Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Chen Q, Wang T, Li J, Wang S, Qiu F, Yu H, Zhang Y, Wang T. Chen Q, et al. Nutrients. 2017 Jan 31;9(2):96. doi: 10.3390/nu9020096. Nutrients. 2017. PMID: 28146130 Free PMC article. Review. - Dietary and commercialized fructose: Sweet or sour?
Yerlikaya A, Dagel T, King C, Kuwabara M, Lanaspa MA, Andres-Hernando A, Covic A, Manitius J, Sag AA, Kanbay M. Yerlikaya A, et al. Int Urol Nephrol. 2017 Sep;49(9):1611-1620. doi: 10.1007/s11255-017-1544-8. Epub 2017 Feb 16. Int Urol Nephrol. 2017. PMID: 28210913 Review. - Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway.
Shen J, Yang X, Meng Z, Guo C. Shen J, et al. Phytomedicine. 2016 Nov 15;23(12):1504-1510. doi: 10.1016/j.phymed.2016.08.009. Epub 2016 Sep 7. Phytomedicine. 2016. PMID: 27765371
Cited by
- Erythrina subumbrans (Hassk) Merr. (Fabaceae) Inhibits Insulin Resistance in the Adipose Tissue of High Fructose-Induced Wistar Rats.
Susilawati E, Levita J, Susilawati Y, Sumiwi SA. Susilawati E, et al. Drug Des Devel Ther. 2024 Aug 27;18:3825-3839. doi: 10.2147/DDDT.S472660. eCollection 2024. Drug Des Devel Ther. 2024. PMID: 39219697 Free PMC article. - Residues in the fructose-binding pocket are required for ketohexokinase-A activity.
Ferreira JC, Villanueva AJ, Fadl S, Al Adem K, Cinviz ZN, Nedyalkova L, Cardoso THS, Andrade ME, Saksena NK, Sensoy O, Rabeh WM. Ferreira JC, et al. J Biol Chem. 2024 Aug;300(8):107538. doi: 10.1016/j.jbc.2024.107538. Epub 2024 Jul 4. J Biol Chem. 2024. PMID: 38971308 Free PMC article. - Effects of tumor necrosis factor-α on glucose uptake in human granulosa cells under high androgen conditions.
Sun D, Zhao Y, Wu X. Sun D, et al. Iran J Basic Med Sci. 2023;26(8):912-918. doi: 10.22038/IJBMS.2023.68784.14993. Iran J Basic Med Sci. 2023. PMID: 37427330 Free PMC article. - Benefits of Valsartan and Amlodipine in Lipolysis through PU.1 Inhibition in Fructose-Induced Adiposity.
Chou CL, Li CH, Fang TC. Chou CL, et al. Nutrients. 2022 Sep 12;14(18):3759. doi: 10.3390/nu14183759. Nutrients. 2022. PMID: 36145135 Free PMC article. - Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance.
Reda D, Elshopakey GE, Mahgoub HA, Risha EF, Khan AA, Rajab BS, El-Boshy ME, Abdelhamid FM. Reda D, et al. Evid Based Complement Alternat Med. 2022 Aug 11;2022:3362005. doi: 10.1155/2022/3362005. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35990819 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous