Lentivirus as a tool for lineage-specific gene manipulations - PubMed (original) (raw)
Lentivirus as a tool for lineage-specific gene manipulations
Anna Malashicheva et al. Genesis. 2007 Jul.
Erratum in
- Genesis. 2007 Dec;45(12):793
Abstract
The trophectoderm (TE) of blastocysts, the first epithelium established in mammalian development, (1) plays signaling, supportive, and patterning functions during preimplantation development, (2) ensures embryo implantation into the uterine wall, and (3) gives rise to extraembryonic tissues essential for embryo patterning and growth after implantation. We show that mouse TE, itself permissive to lentiviral (LV) infection, represents a robust nonpermeable physical barrier to the virus particles, thereby shielding the cells of the inner cell mass from viral infection. This LV feature will allow modulations of gene expression in a lineage-specific manner, thus having significant applications in mouse functional genetics.
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