Plasticity and remodeling of brain - PubMed (original) (raw)
Review
. 2008 Feb 15;265(1-2):97-101.
doi: 10.1016/j.jns.2007.06.013. Epub 2007 Jul 3.
Affiliations
- PMID: 17610903
- DOI: 10.1016/j.jns.2007.06.013
Review
Plasticity and remodeling of brain
Michael Chopp et al. J Neurol Sci. 2008.
Abstract
The injured brain can be stimulated to amplify its intrinsic restorative processes to improve neurological function. Thus, after stroke, both cell and pharmacological neurorestorative treatments, amplify the induction of brain neurogenesis and angiogenesis, and thereby reduce neurological deficits. In this manuscript, we describe the use of bone marrow mesenchymal cells (MSCs) and erythropoietin (EPO) as examples of cell-based and pharmacological neurorestorative treatments, respectively, for both stroke and a mouse model of experimental autoimmune encephalomyelitis (EAE). We demonstrate that these therapies significantly improve neurological function with treatment initiated after the onset of injury and concomitantly promote brain plasticity. The application of MRI to monitor changes in the injured brain associated with reduction of neurological deficit is also described.
Similar articles
- Neurorestorative treatment of stroke: cell and pharmacological approaches.
Chen J, Chopp M. Chen J, et al. NeuroRx. 2006 Oct;3(4):466-73. doi: 10.1016/j.nurx.2006.07.007. NeuroRx. 2006. PMID: 17012060 Free PMC article. Review. - Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.
Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC. Zhao LR, et al. Exp Neurol. 2002 Mar;174(1):11-20. doi: 10.1006/exnr.2001.7853. Exp Neurol. 2002. PMID: 11869029 - Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies.
Chopp M, Li Y, Zhang ZG. Chopp M, et al. Stroke. 2009 Mar;40(3 Suppl):S143-5. doi: 10.1161/STROKEAHA.108.533141. Epub 2008 Dec 8. Stroke. 2009. PMID: 19064763 Free PMC article. - Marrow stromal cell transplantation in stroke and traumatic brain injury.
Li Y, Chopp M. Li Y, et al. Neurosci Lett. 2009 Jun 12;456(3):120-3. doi: 10.1016/j.neulet.2008.03.096. Epub 2009 Jan 17. Neurosci Lett. 2009. PMID: 19429146 Free PMC article. Review. - Promoting recovery from ischemic stroke.
Schmidt A, Minnerup J. Schmidt A, et al. Expert Rev Neurother. 2016;16(2):173-86. doi: 10.1586/14737175.2016.1134324. Epub 2016 Jan 11. Expert Rev Neurother. 2016. PMID: 26689223 Review.
Cited by
- Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A. Abdul Y, et al. Transl Stroke Res. 2021 Aug;12(4):615-630. doi: 10.1007/s12975-020-00844-7. Epub 2020 Sep 1. Transl Stroke Res. 2021. PMID: 32875455 Free PMC article. - Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse.
Xin H, Li Y, Shen LH, Liu X, Wang X, Zhang J, Pourabdollah-Nejad D S, Zhang C, Zhang L, Jiang H, Zhang ZG, Chopp M. Xin H, et al. PLoS One. 2010 Feb 3;5(2):e9027. doi: 10.1371/journal.pone.0009027. PLoS One. 2010. PMID: 20140248 Free PMC article. - Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke.
Dzietko M, Derugin N, Wendland MF, Vexler ZS, Ferriero DM. Dzietko M, et al. Transl Stroke Res. 2013 Apr;4(2):189-200. doi: 10.1007/s12975-012-0221-6. Transl Stroke Res. 2013. PMID: 23926451 Free PMC article. - Mechanisms and targets for angiogenic therapy after stroke.
Navaratna D, Guo S, Arai K, Lo EH. Navaratna D, et al. Cell Adh Migr. 2009 Apr-Jun;3(2):216-23. doi: 10.4161/cam.3.2.8396. Epub 2009 Apr 13. Cell Adh Migr. 2009. PMID: 19363301 Free PMC article. Review. - Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses.
Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S, Prockop DJ. Ohtaki H, et al. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14638-43. doi: 10.1073/pnas.0803670105. Epub 2008 Sep 15. Proc Natl Acad Sci U S A. 2008. PMID: 18794523 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- P01 NS042345/NS/NINDS NIH HHS/United States
- R01 NS045041/NS/NINDS NIH HHS/United States
- P01 NS23393/NS/NINDS NIH HHS/United States
- R01 NS45041/NS/NINDS NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials