Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse - PubMed (original) (raw)
. 2007 Aug;10(8):1029-37.
doi: 10.1038/nn1929. Epub 2007 Jul 8.
Affiliations
- PMID: 17618281
- DOI: 10.1038/nn1929
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
Danielle L Graham et al. Nat Neurosci. 2007 Aug.
Abstract
A single exposure to cocaine rapidly induces the brief activation of several immediate early genes, but the role of such short-term regulation in the enduring consequences of cocaine use is poorly understood. We found that 4 h of intravenous cocaine self-administration in rats induced a transient increase in brain-derived neurotrophic factor (BDNF) and activation of TrkB-mediated signaling in the nucleus accumbens (NAc). Augmenting this dynamic regulation with five daily NAc BDNF infusions caused enduring increases in cocaine self-administration, and facilitated relapse to cocaine seeking in withdrawal. In contrast, neutralizing endogenous BDNF regulation with intra-NAc infusions of antibody to BDNF subsequently reduced cocaine self-administration and attenuated relapse. Using localized inducible BDNF knockout in mice, we found that BDNF originating from NAc neurons was necessary for maintaining increased cocaine self-administration. These findings suggest that dynamic induction and release of BDNF from NAc neurons during cocaine use promotes the development and persistence of addictive behavior.
Comment in
- A role for BDNF in cocaine reward and relapse.
Schoenbaum G, Stalnaker TA, Shaham Y. Schoenbaum G, et al. Nat Neurosci. 2007 Aug;10(8):935-6. doi: 10.1038/nn0807-935. Nat Neurosci. 2007. PMID: 17657232 Free PMC article.
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