Erythropoietin and treatment of non-anemic conditions--cardiovascular protection - PubMed (original) (raw)
Review
Erythropoietin and treatment of non-anemic conditions--cardiovascular protection
Danilo Fliser et al. Semin Hematol. 2007 Jul.
Abstract
The well-established physiological function of erythropoietin (EPO) is the induction of erythropoiesis. A growing body of evidence indicates that EPO has tissue-protective effects and prevents tissue damage during ischemia and inflammation. Tissue protection after ischemia and injury has been found in the brain, heart, and kidney. It has been speculated that EPO has anti-apoptotic effects in cardiovascular cells. These novel effects of EPO seem to be independent of its erythropoietic activity. Unclear is the role of the known EPO receptor or whether other signaling pathways are involved; a novel EPO receptor might be involved in tissue protection by this hormone. This review article summarizes present knowledge of cardiovascular and renal protective effects of EPO and discusses possible underlying mechanisms.
Similar articles
- Mechanisms of disease: erythropoietin--an old hormone with a new mission?
Fliser D, Bahlmann FH, deGroot K, Haller H. Fliser D, et al. Nat Clin Pract Cardiovasc Med. 2006 Oct;3(10):563-72. doi: 10.1038/ncpcardio0609. Nat Clin Pract Cardiovasc Med. 2006. PMID: 16990842 Review. - The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors.
Brines M. Brines M. Blood Purif. 2010;29(2):86-92. doi: 10.1159/000245630. Epub 2010 Jan 8. Blood Purif. 2010. PMID: 20093809 Review. - Erythropoietin and the endothelium - a promising link?
Fliser D, Bahlmann FH. Fliser D, et al. Eur J Clin Invest. 2008 Jul;38(7):457-61. doi: 10.1111/j.1365-2362.2008.01968.x. Epub 2008 May 21. Eur J Clin Invest. 2008. PMID: 18505404 Review. - [Pleiotropic effects of erythropoietin].
Kes P, Basić-Jukić N, Furić-Cunko V. Kes P, et al. Acta Med Croatica. 2009 Sep;63 Suppl 1:46-53. Acta Med Croatica. 2009. PMID: 20232551 Review. Croatian. - Experimental models of acute renal failure and erythropoietin: what evidence of a direct effect?
Sturiale A, Campo S, Crascì E, Aloisi C, Buemi M. Sturiale A, et al. Ren Fail. 2007;29(3):379-86. doi: 10.1080/08860220701193290. Ren Fail. 2007. PMID: 17497457 Review.
Cited by
- Erythropoietin receptor response circuits.
Wojchowski DM, Sathyanarayana P, Dev A. Wojchowski DM, et al. Curr Opin Hematol. 2010 May;17(3):169-76. doi: 10.1097/MOH.0b013e328338008b. Curr Opin Hematol. 2010. PMID: 20173635 Free PMC article. Review. - Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice.
Eliopoulos N, Zhao J, Forner K, Birman E, Young YK, Bouchentouf M. Eliopoulos N, et al. Mol Ther. 2011 Nov;19(11):2072-83. doi: 10.1038/mt.2011.162. Epub 2011 Aug 16. Mol Ther. 2011. PMID: 21847101 Free PMC article. - Polycythemia in dogs with chronic hypoxic pulmonary disease.
Holopainen S, Laurila HP, Lappalainen AK, Rajamäki MM, Viitanen SJ. Holopainen S, et al. J Vet Intern Med. 2022 Jul;36(4):1202-1210. doi: 10.1111/jvim.16466. Epub 2022 Jun 14. J Vet Intern Med. 2022. PMID: 35702817 Free PMC article. - Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies.
Maiese K, Chong ZZ, Li F, Shang YC. Maiese K, et al. Prog Neurobiol. 2008 Jun;85(2):194-213. doi: 10.1016/j.pneurobio.2008.02.002. Epub 2008 Mar 4. Prog Neurobiol. 2008. PMID: 18396368 Free PMC article. Review. - Restoration of Haemoglobin Level Using Hydrodynamic Gene Therapy with Erythropoietin Does Not Alleviate the Disease Progression in an Anaemic Mouse Model for TGFβ1-Induced Chronic Kidney Disease.
Pedersen L, Wogensen L, Marcussen N, Cecchi CR, Dalsgaard T, Dagnæs-Hansen F. Pedersen L, et al. PLoS One. 2015 Jun 5;10(6):e0128367. doi: 10.1371/journal.pone.0128367. eCollection 2015. PLoS One. 2015. PMID: 26046536 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials