Tumor growth need not be driven by rare cancer stem cells - PubMed (original) (raw)
. 2007 Jul 20;317(5836):337.
doi: 10.1126/science.1142596.
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- PMID: 17641192
- DOI: 10.1126/science.1142596
Tumor growth need not be driven by rare cancer stem cells
Priscilla N Kelly et al. Science. 2007.
Abstract
The cancer stem cell hypothesis postulates that tumor growth is driven by a rare subpopulation of tumor cells. Much of the supporting evidence for this intriguing idea is derived from xenotransplantation experiments in which human leukemia cells are grown in immunocompromised mice. We show that, when lymphomas and leukemias of mouse origin are transplanted into histocompatible mice, a very high frequency (at least 1 in 10) of the tumor cells can seed tumor growth. We suggest that the low frequency of tumor-sustaining cells observed in xenotransplantation studies may reflect the limited ability of human tumor cells to adapt to growth in a foreign (mouse) milieu.
Comment in
- Comment on "Tumor growth need not be driven by rare cancer stem cells".
Kennedy JA, Barabé F, Poeppl AG, Wang JC, Dick JE. Kennedy JA, et al. Science. 2007 Dec 14;318(5857):1722; author reply 1722. doi: 10.1126/science.1149590. Science. 2007. PMID: 18079385
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