Biological aspects of cytosine methylation in eukaryotic cells - PubMed (original) (raw)
Review
. 1991 Dec 1;47(11-12):1171-85.
doi: 10.1007/BF01918381.
Affiliations
- PMID: 1765128
- DOI: 10.1007/BF01918381
Review
Biological aspects of cytosine methylation in eukaryotic cells
M Hergersberg. Experientia. 1991.
Abstract
The existence in eukaryotes of a fifth base, 5-methylcytosine, and of tissue-specific methylation patterns have been known for many years, but except for a general association with inactive genes and chromatin the exact function of this DNA modification has remained elusive. The different hypotheses regarding the role of DNA methylation in regulation of gene expression, chromatin structure, development, and diseases, including cancer are summarized, and the experimental evidence for them is discussed. Structural and functional properties of the eukaryotic DNA cytosine methyltransferase are also reviewed.
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References
- Nucleic Acids Res. 1980 Apr 11;8(7):1485-97 - PubMed
- Genes Dev. 1989 Nov;3(11):1669-76 - PubMed
- Am J Med Genet. 1990 Mar;35(3):333-49 - PubMed
- Genes Dev. 1990 Mar;4(3):331-43 - PubMed
- Biochem Biophys Res Commun. 1989 May 15;160(3):1175-82 - PubMed