Unravelling the pathogenesis of inflammatory bowel disease - PubMed (original) (raw)

Review

. 2007 Jul 26;448(7152):427-34.

doi: 10.1038/nature06005.

Affiliations

• PMID: 17653185
• DOI: 10.1038/nature06005

Review

Unravelling the pathogenesis of inflammatory bowel disease

R J Xavier et al. Nature. 2007.

Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

PubMed Disclaimer

Similar articles

• Etiology and pathogenesis of inflammatory bowel disease.
  Schmidt C, Stallmach A. Schmidt C, et al. Minerva Gastroenterol Dietol. 2005 Jun;51(2):127-45. Minerva Gastroenterol Dietol. 2005. PMID: 15990703 Review.
• Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine.
  Goyette P, Labbé C, Trinh TT, Xavier RJ, Rioux JD. Goyette P, et al. Ann Med. 2007;39(3):177-99. doi: 10.1080/07853890701197615. Ann Med. 2007. PMID: 17457716 Review.
• [Inflammatory bowel disease: IBD].
  Endo K, Shiga H, Kinouchi Y, Shimosegawa T. Endo K, et al. Rinsho Byori. 2009 Jun;57(6):527-32. Rinsho Byori. 2009. PMID: 19621784 Review. Japanese.
• Role of the innate immune system in the pathogenesis of inflammatory bowel disease.
  van Lierop PP, Samsom JN, Escher JC, Nieuwenhuis EE. van Lierop PP, et al. J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):142-51. doi: 10.1097/MPG.0b013e3181821964. J Pediatr Gastroenterol Nutr. 2009. PMID: 19179875 Review.
• Expression signatures, barriers and beyond: the role of oxidative stress in murine colitis and human inflammatory bowel disease revisited.
  Rosenstiel P, Schreiber S. Rosenstiel P, et al. Eur J Gastroenterol Hepatol. 2008 Jun;20(6):496-9. doi: 10.1097/MEG.0b013e3282f45774. Eur J Gastroenterol Hepatol. 2008. PMID: 18467906 Review.

Cited by

• A study of the effects of Cydonia oblonga Miller (Quince) on TNBS-induced ulcerative colitis in rats.
  Minaiyan M, Ghannadi A, Etemad M, Mahzouni P. Minaiyan M, et al. Res Pharm Sci. 2012 Apr;7(2):103-10. Res Pharm Sci. 2012. PMID: 23181087 Free PMC article.
• M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
  Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX. Zhou XL, et al. Front Pharmacol. 2020 Sep 11;11:557312. doi: 10.3389/fphar.2020.557312. eCollection 2020. Front Pharmacol. 2020. PMID: 33041798 Free PMC article.
• Cyanidin-3-_O_-glucoside extracted from the Chinese bayberry (Myrica rubra Sieb. et Zucc.) alleviates antibiotic-associated diarrhea by regulating gut microbiota and down-regulating inflammatory factors in NF-κB pathway.
  Wang Y, Chen J, Wang Y, Zheng F, Qu M, Huang Z, Yan J, Bao F, Li X, Sun C, Zheng Y. Wang Y, et al. Front Nutr. 2022 Aug 24;9:970530. doi: 10.3389/fnut.2022.970530. eCollection 2022. Front Nutr. 2022. PMID: 36091245 Free PMC article.
• Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
  Murata Y, Kotani T, Supriatna Y, Kitamura Y, Imada S, Kawahara K, Nishio M, Daniwijaya EW, Sadakata H, Kusakari S, Mori M, Kanazawa Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H, Azuma T, Suzuki A, Matozaki T. Murata Y, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4264-71. doi: 10.1073/pnas.1510167112. Epub 2015 Jul 20. Proc Natl Acad Sci U S A. 2015. PMID: 26195794 Free PMC article.
• Oral Nanomedicines for siRNA Delivery to Treat Inflammatory Bowel Disease.
  Shinn J, Lee J, Lee SA, Lee SJ, Choi AH, Kim JS, Kim SJ, Kim HJ, Lee C, Kim Y, Kim J, Choi J, Jung B, Kim T, Nam H, Kim H, Lee Y. Shinn J, et al. Pharmaceutics. 2022 Sep 19;14(9):1969. doi: 10.3390/pharmaceutics14091969. Pharmaceutics. 2022. PMID: 36145716 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)