Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition - PubMed (original) (raw)

Review

. 2007 Oct;19(10):2003-12.

doi: 10.1016/j.cellsig.2007.05.013. Epub 2007 Jun 12.

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Review

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

Katherine Holmes et al. Cell Signal. 2007 Oct.

Abstract

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.

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