Astrocyte glycogen and brain energy metabolism - PubMed (original) (raw)
Review
. 2007 Sep;55(12):1263-1271.
doi: 10.1002/glia.20557.
Affiliations
- PMID: 17659525
- DOI: 10.1002/glia.20557
Review
Astrocyte glycogen and brain energy metabolism
Angus M Brown et al. Glia. 2007 Sep.
Abstract
The brain contains glycogen but at low concentration compared with liver and muscle. In the adult brain, glycogen is found predominantly in astrocytes. Astrocyte glycogen content is modulated by a number of factors including some neurotransmitters and ambient glucose concentration. Compelling evidence indicates that astrocyte glycogen breaks down during hypoglycemia to lactate that is transferred to adjacent neurons or axons where it is used aerobically as fuel. In the case of CNS white matter, this source of energy can extend axon function for 20 min or longer. Likewise, during periods of intense neural activity when energy demand exceeds glucose supply, astrocyte glycogen is degraded to lactate, a portion of which is transferred to axons for fuel. Astrocyte glycogen, therefore, offers some protection against hypoglycemic neural injury and ensures that neurons and axons can maintain their function during very intense periods of activation. These emerging principles about the roles of astrocyte glycogen contradict the long held belief that this metabolic pool has little or no functional significance.
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References
REFERENCES
- Allaman I, Pellerin L, Magistretti PJ. 2000. Protein targeting to glycogen (PTG) mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes. Glia 30: 382-391.
- Ames AIII. 2000. CNS energy metabolism as related to function. Brain Res Brain Res Rev 34: 42-68.
- Auer RN. 2004. Hypoglycemic brain damage. Metab Brain Dis 19: 169-175.
- Bachelard HS. 1980. Glucose transport to the brain in vivo and in vitro. In: Passonneau JV, Hawkins RA, Lust WD, Welsh F, editors. Cerebral metabolism and neural function. Baltimore: Williams and Wilkins. pp 106-119.
- Bergersen LH, Magistretti PJ, Pellerin L. 2005. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Cereb Cortex 15: 361-370.
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