Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis - PubMed (original) (raw)
. 2007 Sep;39(9):1108-13.
doi: 10.1038/ng2106. Epub 2007 Jul 29.
Kristina Duvefelt, Ellen Iacobaeus, Ingrid Kockum, Erik Wallström, Mohsen Khademi, Annette Oturai, Lars P Ryder, Janna Saarela, Hanne F Harbo, Elisabeth G Celius, Hugh Salter, Tomas Olsson, Jan Hillert
Affiliations
- PMID: 17660816
- DOI: 10.1038/ng2106
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
Frida Lundmark et al. Nat Genet. 2007 Sep.
Abstract
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, despite considerable efforts. Polymorphisms in a number of non-HLA genes have been reported to be associated with multiple sclerosis, but so far confirmation has been difficult. Here, we report compelling evidence that polymorphisms in IL7R, which encodes the interleukin 7 receptor alpha chain (IL7Ralpha), indeed contribute to the non-HLA genetic risk in multiple sclerosis, demonstrating a role for this pathway in the pathophysiology of this disease. In addition, we report altered expression of the genes encoding IL7Ralpha and its ligand, IL7, in the cerebrospinal fluid compartment of individuals with multiple sclerosis.
Comment in
- IL-7Ralpha and multiple sclerosis risk.
Harley JB. Harley JB. Nat Genet. 2007 Sep;39(9):1053-4. doi: 10.1038/ng0907-1053. Nat Genet. 2007. PMID: 17728770 No abstract available.
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