Low vitamin B6 levels and the risk of recurrent venous thromboembolism - PubMed (original) (raw)

doi: 10.3324/haematol.11318. Epub 2007 Aug 1.

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• PMID: 17666362
• DOI: 10.3324/haematol.11318

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Low vitamin B6 levels and the risk of recurrent venous thromboembolism

Gregor Hron et al. Haematologica. 2007 Sep.

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Abstract

Low plasma vitamin B6, measured as pyridoxal-5'-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence among patients with PLP < or =23.3 nmol/L and 14.4% (11.5%-17.4%) among those with PLP >23.3 nmol/L was 22.5% (95% CI 13.6%-31.5%) (p=0.01). Patients with PLP ''23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.

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