Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera - PubMed (original) (raw)

Case Reports

. 2007 Sep 1;196(5):709-11.

doi: 10.1086/520514. Epub 2007 Jul 13.

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• PMID: 17674313
• DOI: 10.1086/520514

Case Reports

Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera

Susama Verma et al. J Infect Dis. 2007.

Abstract

Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.

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Comment in

• 5-HT2a inhibitors for progressive multifocal leukoencephalopathy: old drugs for an old disease.
  Focosi D, Kast RE, Maggi F, Lauria G, Ceccherini-Nelli L, Petrini M. Focosi D, et al. J Infect Dis. 2008 Jan 15;197(2):328; author reply 328-9. doi: 10.1086/524877. J Infect Dis. 2008. PMID: 18194091 No abstract available.

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