Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing - PubMed (original) (raw)
. 2007 Sep 1;79(17):6697-701.
doi: 10.1021/ac071062b. Epub 2007 Aug 3.
Affiliations
- PMID: 17676761
- DOI: 10.1021/ac071062b
Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing
Alastair W Wark et al. Anal Chem. 2007.
Abstract
Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
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