Pathway of membrane fusion with two tension-dependent energy barriers - PubMed (original) (raw)
. 2007 May 25;98(21):218101.
doi: 10.1103/PhysRevLett.98.218101. Epub 2007 May 23.
Affiliations
- PMID: 17677811
- DOI: 10.1103/PhysRevLett.98.218101
Pathway of membrane fusion with two tension-dependent energy barriers
Andrea Grafmüller et al. Phys Rev Lett. 2007.
Abstract
Fusion of bilayer membranes is studied via dissipative particle dynamics (DPD) simulations. A new set of DPD parameters is introduced which leads to an energy barrier for flips of lipid molecules between adhering membranes. A large number of fusion events is monitored for a vesicle in contact with a planar membrane. Several time scales of the fusion process are found to depend exponentially on the membrane tension. This implies an energy barrier of about 10k(B)T for intermembrane flips and a second size-dependent barrier for the nucleation of a small hemifused membrane patch.
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