Hepatitis B prophylaxis in patients undergoing chemotherapy for lymphoma: a decision analysis model - PubMed (original) (raw)

Comparative Study

. 2007 Oct;46(4):1049-56.

doi: 10.1002/hep.21783.

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Comparative Study

Hepatitis B prophylaxis in patients undergoing chemotherapy for lymphoma: a decision analysis model

Sammy Saab et al. Hepatology. 2007 Oct.

Abstract

Hepatitis B reactivation is a major cause of morbidity and mortality in patients undergoing chemotherapy for lymphomas. These patients may experience direct liver-related complications or reduced cancer survival because of interruptions in chemotherapy. Our aim was to compare the costs and outcomes of 2 different chronic hepatitis B management strategies. In hepatitis B carriers undergoing chemotherapy, we pursued a decision analysis model to compare the costs and clinical outcomes of using lamivudine prophylaxis versus initiating lamivudine only when clinically overt hepatitis occurred. Our results indicate that the use of lamivudine prophylaxis is cost-effective. Even though the use of lamivudine prophylaxis was associated with an incremental cost of 1530perpatient(1530 per patient (1530perpatient(18,707 versus 17,177),boththenumberandseverityofhepatitisBreactivationswerereduced.Noneofthepatientsintheprophylaxisgrouphadliver−relateddeathsversus20whodiedintheno−prophylaxisgroup.Cancerdeathswerealsoreducedfrom47−39withlamivudineprophylaxis,presumablybecauseoftheincreasedneedforcessationormodificationofchemotherapyinpatientswhohadseverehepatitisBvirusflares.Theincrementalcost−effectivenessratioofusinglamivudineprophylaxiswas17,177), both the number and severity of hepatitis B reactivations were reduced. None of the patients in the prophylaxis group had liver-related deaths versus 20 who died in the no-prophylaxis group. Cancer deaths were also reduced from 47-39 with lamivudine prophylaxis, presumably because of the increased need for cessation or modification of chemotherapy in patients who had severe hepatitis B virus flares. The incremental cost-effectiveness ratio of using lamivudine prophylaxis was 17,177),boththenumberandseverityofhepatitisBreactivationswerereduced.Noneofthepatientsintheprophylaxisgrouphadliver−relateddeathsversus20whodiedintheno−prophylaxisgroup.Cancerdeathswerealsoreducedfrom47−39withlamivudineprophylaxis,presumablybecauseoftheincreasedneedforcessationormodificationofchemotherapyinpatientswhohadseverehepatitisBvirusflares.Theincrementalcost−effectivenessratioofusinglamivudineprophylaxiswas33,514 per life year saved.

Conclusion: Our results provide pharmacoeconomic support for the use of lamivudine prophylaxis in patients undergoing chemotherapy for lymphoma treatment.

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