Loss of pregnancy-associated plasma protein A extends lifespan in mice - PubMed (original) (raw)
Loss of pregnancy-associated plasma protein A extends lifespan in mice
Cheryl A Conover et al. Aging Cell. 2007 Oct.
Free article
Abstract
Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.
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