RNA polymerase: the most specific damage recognition protein in cellular responses to DNA damage? - PubMed (original) (raw)

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RNA polymerase: the most specific damage recognition protein in cellular responses to DNA damage?

Laura A Lindsey-Boltz et al. Proc Natl Acad Sci U S A. 2007.

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.

RNAP II as the universal high-specificity damage sensor for three major cellular responses to bulky DNA lesions, such as the cyclobutane pyrimidine dimers induced by UV light. RNAP II arrests at a dimer site in the transcribed strand. The resulting structure recruits proteins that initiate repair, cell cycle checkpoints, or apoptosis.

Fig. 2.

Potential DNA damage detection mechanisms for initiating checkpoint responses. The primary damage itself may be recognized by damage-specific proteins that may activate the checkpoint directly. Alternatively, the stalled RNAP II constitutes the checkpoint signal and recruits checkpoint kinase ATR. RPA-coated single-stranded DNA gaps generated by nucleotide excision repair and the extensive RPA-coated single-stranded DNA generated by replication forks stalled at a damage site are known to be strong signals for checkpoint activation.

Comment on

• RPA and ATR link transcriptional stress to p53.
  Derheimer FA, O'Hagan HM, Krueger HM, Hanasoge S, Paulsen MT, Ljungman M. Derheimer FA, et al. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12778-83. doi: 10.1073/pnas.0705317104. Epub 2007 Jul 6. Proc Natl Acad Sci U S A. 2007. PMID: 17616578 Free PMC article.

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