Association of PTPN22 with rheumatoid arthritis among South Asians in the UK - PubMed (original) (raw)
. 2007 Oct;34(10):1984-6.
Epub 2007 Aug 1.
Affiliations
- PMID: 17696275
Association of PTPN22 with rheumatoid arthritis among South Asians in the UK
Sarabjit Mastana et al. J Rheumatol. 2007 Oct.
Abstract
Objective: To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls.
Methods: DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method.
Results: The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68-20.52). Similar association was observed for genotypes containing *T allele.
Conclusion: Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians.
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